National Research Council of Italy, Institute for Biomedical Research and Innovation (IRIB), Palermo, Italy.
National Research Council of Italy, Institute of Translational Pharmacology (IFT), Palermo, Italy.
PLoS One. 2022 Oct 14;17(10):e0276217. doi: 10.1371/journal.pone.0276217. eCollection 2022.
Obstructive sleep apnea (OSA) is a common, prevalent, and underdiagnosed disorder. Its lack of diagnosis and treatment is associated with increased morbidity and mortality. Previous screening questionnaires investigated parameters including body mass index, age, neck circumference, and sex, in addition to symptoms. This study aimed to validate a new Italian, self-administered, and easy-to-use six-item questionnaire that evaluates only subjective symptoms.
The present study included 2622 patients (male, 2011; female, 611). Patients who were at least 18 years old, spoke Italian, referred to our sleep clinic for possible OSA, and completed the self-administered SANReSP questionnaire were recruited for the study. The predictive performance of the questionnaire was also evaluated.
Nocturnal study showed 89.9% of OSA patients had apnea-hypopnea index (AHI) ≥ 5/h; 68.7%, AHI ≥ 15/h; and 48.2%, AHI ≥ 30/h. The optimal SANReSP score for AHI ≥ 5/h was >3 with a sensitivity and specificity of 74.76% and 67.92%, respectively, and an area under receiver operating characteristic curve (ROC) of 0.76. For moderate-severe OSA, the optimal SANReSP score was >3 (sensitivity, 78.18%; specificity, 46.53%; ROC, 0.66). For severe OSA, the optimal SANReSP score was >4 (sensitivity, 59.10%; specificity, 64.73%; ROC, 0.65). The probability of OSA increased with higher SANReSP scores (98.7% and 97.9% in men and women, respectively).
The SANReSP questionnaire is a short, easy-to-use, and self-administered screening tool for OSA. Its performance is similar to that of other widely used questionnaires; furthermore, it is advantageous in that it does not require anthropometric measurements.
阻塞性睡眠呼吸暂停（OSA）是一种常见、普遍且未被充分诊断的疾病。其诊断和治疗的缺失与发病率和死亡率的增加有关。先前的筛查问卷调查了包括体重指数、年龄、颈围和性别在内的参数，以及症状。本研究旨在验证一种新的意大利语、自我管理且易于使用的六项目问卷，该问卷仅评估主观症状。
本研究纳入了 2622 名患者（男性 2011 名，女性 611 名）。年龄至少 18 岁、会说意大利语、因可能患有 OSA 而到我们的睡眠诊所就诊、并完成自我管理的 SANReSP 问卷的患者被纳入本研究。还评估了问卷的预测性能。
夜间研究显示，89.9%的 OSA 患者呼吸暂停低通气指数（AHI）≥5/h；68.7%，AHI≥15/h；48.2%，AHI≥30/h。对于 AHI≥5/h，最佳的 SANReSP 评分>3，灵敏度和特异性分别为 74.76%和 67.92%，受试者工作特征曲线（ROC）下面积为 0.76。对于中重度 OSA，最佳的 SANReSP 评分>3（灵敏度 78.18%；特异性 46.53%；ROC 0.66）。对于重度 OSA，最佳的 SANReSP 评分>4（灵敏度 59.10%；特异性 64.73%；ROC 0.65）。随着 SANReSP 评分的升高，OSA 的可能性增加（男性分别为 98.7%和 97.9%，女性分别为 98.7%和 97.9%）。
SANReSP 问卷是一种用于 OSA 的简短、易于使用且自我管理的筛查工具。其性能与其他广泛使用的问卷相似；此外，它的优势在于它不需要人体测量。
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