Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Adv Colloid Interface Sci. 2022 Nov;309:102795. doi: 10.1016/j.cis.2022.102795. Epub 2022 Oct 7.
In recent years, the second-highest mortality rate of any cancer worldwide has been breast cancer (BC), which is one of the three most common and deadly cancers among women. Detecting BC in its earliest stages facilitates treatment, reduces death risk, and improves survival rates for patients. Biosensors have garnered considerable attention in recent years for the early diagnosis of BC owing to their high sensitivity, simplicity, low cost, and low detection limit compared to other diagnostic technologies. Polymer nanocomposites (PNCs) containing conductive nanoparticles (NPs) have been used as electrochemical biosensors. In this study, we review recent developments in electrochemical biosensors based on PNCs containing metallic NPs and carbon nanomaterials (carbon nanotubes and graphene) for the diagnosis of biomarkers associated with BC. The key performance characteristics of electrochemical biosensors, such as linear detection range, limit of detection (LOD), and response time, along with the numerous BC biomarkers and various NPs for the fabrication of biosensors are discussed. Additionally, future challenges of electrochemical biosensors and hindrances to their use in clinical practice are explored.
近年来，全球死亡率第二高的癌症是乳腺癌（BC），它是女性中最常见和最致命的三种癌症之一。早期发现乳腺癌有助于治疗、降低死亡风险并提高患者的生存率。与其他诊断技术相比，生物传感器具有高灵敏度、简单、低成本和低检测限等优点，近年来在乳腺癌的早期诊断中受到了广泛关注。含有导电纳米颗粒（NPs）的聚合物纳米复合材料（PNCs）已被用作电化学生物传感器。在本研究中，我们综述了基于含有金属 NPs 和碳纳米材料（碳纳米管和石墨烯）的 PNCs 的电化学生物传感器在用于诊断与乳腺癌相关的生物标志物方面的最新进展。讨论了电化学生物传感器的关键性能特征，如线性检测范围、检测限（LOD）和响应时间，以及用于生物传感器制造的许多乳腺癌生物标志物和各种 NPs。此外，还探讨了电化学生物传感器的未来挑战和在临床实践中应用的障碍。
