Branch C L, Laws E R
J Clin Endocrinol Metab. 1987 Sep;65(3):469-74. doi: 10.1210/jcem-65-3-469.
Tumors metastatic to the pituitary gland are uncommon, but may mimic a typical pituitary adenoma and are an important part of the differential diagnosis of sellar mass lesions. Pituitary metastases were treated by transsphenoidal microsurgical removal in 14 patients. Most tumors appeared in men in the sixth and seventh decades of life. Half of the patients presented with visual loss, 6 had anterior hypopituitarism, and 4 had diabetes insipidus. Primary cancer had been diagnosed and treated previously in 5 patients. In the remaining 9 patients, the transsphenoidal operation provided the initial diagnosis of cancer, and primary lesions subsequently were detected in all but 2. Transsphenoidal surgery also provided satisfactory decompression of the mass effect related to the tumors, improving the presenting symptoms in the majority of patients, and the surgery was free of mortality or serious complications.
转移至垂体的肿瘤并不常见，但可能酷似典型的垂体腺瘤，是鞍区占位性病变鉴别诊断的重要组成部分。14例垂体转移瘤患者接受了经蝶窦显微手术切除治疗。大多数肿瘤出现在60和70岁的男性中。半数患者出现视力丧失，6例有垂体前叶功能减退，4例有尿崩症。5例患者之前已诊断并治疗过原发性癌症。在其余9例患者中，经蝶窦手术提供了癌症的初步诊断，除2例之外，随后均检测到了原发性病变。经蝶窦手术还对与肿瘤相关的占位效应提供了满意的减压效果，改善了大多数患者的症状，且手术无死亡或严重并发症。
