[Risk factors for COVID-19 severe complications comparing three major epidemiological waves: An approach from primary health care in Mexico].

OBJECTIVES

To describe the association between chronic noncommunicable diseases and age with hospitalization, death and severe clinical outcomes for COVID-19 in confirmed cases within the mexican population, comparing the first three epidemiological waves of the pandemic in Mexico.

DESIGN

We performed an analysis using Mexico's Government Epidemiological Surveillance System database for COVID-19.

EMPLACEMENT

Mexico's Epidemiological Surveillance System for Respiratory Diseases.

PARTICIPANTS

Mexican population confirmed with SARS-CoV-2 registered on Mexico's Epidemiological Surveillance System for Respiratory Diseases.

PRIMARY MEASUREMENTS

The analysed severe outcomes were hospitalization, pneumonia, use of mechanical ventilation, intensive care unit admission and death. The association (odds ratio) between the outcomes and clinical variables was evaluated, comparing the three epidemiological waves in Mexico.

RESULTS

Age over 65 is associated with a higher ratio of hospitalization and pneumonia, independent of the effect of chronic comorbidities. There is an interaction between age and obesity, which is associated with hospitalization, pneumonia and highly associated with death. These findings were consistent throughout the three epidemiological waves.

CONCLUSION

Obesity, COPD and diabetes in interaction with age, are associated with worse clinical outcomes and, more importantly, death in patients with COVID-19.