Demirdöğen Birsen Can
Department of Biomedical Engineering, TOBB University of Economics and Technology, Söğütözü, Ankara 06560, Turkey.
Mult Scler Relat Disord. 2022 Dec;68:104232. doi: 10.1016/j.msard.2022.104232. Epub 2022 Oct 8.
Nanomedicine offers great promise to solve healthcare problems using nanotechnology. Theranostics provide imaging/diagnosis and therapy simultaneously. Novel agents that target both the neuroinflammation and neurodegeneration component of multiple sclerosis (MS) are required. Progress has been achieved in developing smart, surface decorated nanoparticles that effectively transport the therapeutic drug into the central nervous system (CNS). Graphene quantum dots (GQDs) can be traced in vivo by fluorescence imaging due to their unique optical properties. They can also traverse the blood-brain barrier (BBB) and deliver drugs into the CNS. Moreover, GQDs have low cytotoxicity and higher biocompatibility. Therefore, GQDs can be utilized to design novel multifunctional nanocarrier theranostic tools for MS.
纳米医学有望利用纳米技术解决医疗保健问题。治疗诊断学可同时提供成像/诊断和治疗。需要针对多发性硬化症（MS）的神经炎症和神经退行性变成分的新型药物。在开发能够有效将治疗药物输送到中枢神经系统（CNS）的智能、表面修饰纳米颗粒方面已经取得了进展。由于其独特的光学性质，石墨烯量子点（GQDs）可以通过荧光成像在体内进行追踪。它们还可以穿越血脑屏障（BBB）并将药物输送到中枢神经系统。此外，GQDs具有低细胞毒性和更高的生物相容性。因此，GQDs可用于设计用于MS的新型多功能纳米载体治疗诊断工具。
