Department of Hygiene and Epidemiology, Medical University of Lublin, Poland.
Department of Dermatology, Venerology and Pediatric Dermatology, Independent Public Healthcare Unit No.1 in Lublin, Poland.
Biomed Pharmacother. 2022 Dec;156:113785. doi: 10.1016/j.biopha.2022.113785. Epub 2022 Oct 14.
Vitiligo is a depigmentation skin disease often coexisting with other autoimmune disorders. The prevalence is 0.5-2 % of the world's population. A combination of genetic, environmental and biochemical factors play a role in pathogenesis of the disease. The aim of the study was to measure selected cytokines in the blood sera of patients with vitiligo and to select the best marker of the disease. The study was conducted on 50 patients with vitiligo and 38 controls. The type of vitiligo, body surface area (BSA), disease advancement assessment according to Vitiligo European Task Force, the degree of skin involvement and degree of progression were measured. Patients' skin phototype was determined according to Fitzpatrick's classification. Medical history was recorded. Venous blood samples were obtained, The sera were used for laboratory test. Determinations of IL-17, IL-22 and IL-23 were performed using the enzyme-linked immunoabsorbent assay. In the study group 4 cases had phototype I, 38 II, 8 III. In the control group: 3, 29, 6, respectively. Universal vitiligo was found in 38 patients, segmental in 2, acro-facial in 10. In all cases VETF was + 1. Hypothyroidism was recorded in the medical histories of 11 cases vs 2 controls. Significantly higher concentrations of IL-22 and IL-23 were in cases vs controls. IL-22 concentrations were significantly higher in the study group with BSA ≤ 10 than in the control group, and in the group with BSA ≥ 10 they were the highest (p < 0.05). IL-22 is the best marker of active universal type vitiligo, it is directly proportional to the extent of lesions.
白癜风是一种常见的色素减退性皮肤病，常伴有其他自身免疫性疾病。其患病率为全球人口的 0.5-2%。遗传、环境和生化因素的综合作用在疾病的发病机制中起作用。本研究的目的是测量白癜风患者血清中选定的细胞因子，并选择疾病的最佳标志物。该研究在 50 名白癜风患者和 38 名对照者中进行。测量了白癜风的类型、体表面积（BSA）、根据欧洲白癜风工作组的疾病进展评估、皮肤受累程度和进展程度。根据 Fitzpatrick 分类法确定患者的皮肤光型。记录了病史。采集静脉血样，血清用于实验室检测。采用酶联免疫吸附试验测定 IL-17、IL-22 和 IL-23。在研究组中，4 例为 I 型光型，38 例为 II 型，8 例为 III 型。在对照组中：分别为 3、29、6。38 例为全身性白癜风，2 例为节段性白癜风，10 例为肢端-面部白癜风。在所有病例中，VETF 均为+1。11 例病例中有甲状腺功能减退病史，对照组为 2 例。病例组的 IL-22 和 IL-23 浓度明显高于对照组。BSA≤10 的研究组 IL-22 浓度明显高于对照组，BSA≥10 的组中浓度最高（p<0.05）。IL-22 是活动性全身性白癜风的最佳标志物，与病变程度直接相关。
