Sauer M V, Stumpf P G, Rodi I A, Gorrill M J, Simon J A, Buster J E
Hum Reprod. 1987 May;2(4):287-9. doi: 10.1093/oxfordjournals.humrep.a136536.
Using a polysiloxane cylinder impregnated with crystalline progesterone (P4), combined with a 17 beta-oestradiol (E2) and P4 vaginal ring, we produced first trimester pregnancy levels of serum P4 in six functionally agonadal women scheduled for transfer of donated embryos. With this 4 g P4 cylinder worn from cycle day 15 to day 30, overall mean serum P4 concentrations were 15.03 +/- 1.56 ng/ml, with a mean peak level of 21.34 +/- 1.85 ng/ml. These levels were significantly higher than those obtained by us previously in five subjects using a 2 g P4 cylinder [P = 0.007]. The cylinder produced minor but significant complications including small vulvovaginal lacerations, difficulty in removing the device, and vaginal discharge. We conclude that the steroid impregnated polysiloxane vaginal ring and cylinder system provides: continuous and sustained hormone release, and levels of serum P4 in the normal range for early pregnancy. Side effects however, may limit its clinical usefulness.
我们使用了一个浸渍有结晶孕酮（P4）的聚硅氧烷柱体，并结合17β - 雌二醇（E2）和P4阴道环，在六名计划移植捐赠胚胎的功能性性腺功能不全的女性中产生了孕早期血清P4水平。在周期第15天至第30天佩戴这个4g的P4柱体后，血清P4总体平均浓度为15.03±1.56ng/ml，平均峰值水平为21.34±1.85ng/ml。这些水平显著高于我们之前在五名受试者中使用2g P4柱体所获得的水平[P = 0.007]。该柱体产生了轻微但显著的并发症，包括小的外阴阴道撕裂伤、取出装置困难和阴道分泌物。我们得出结论，类固醇浸渍的聚硅氧烷阴道环和柱体系统提供：持续且稳定的激素释放，以及处于早孕正常范围内的血清P4水平。然而，副作用可能会限制其临床应用。
