Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin, China,
Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin, China.
Neuroepidemiology. 2022;56(6):452-459. doi: 10.1159/000527437. Epub 2022 Oct 14.
Several reports have described glioma following different cancers. We assessed the prevalence of primary malignant brain tumors afterward systemic malignancies in patients in the USA based on Surveillance, Epidemiology, and End Results (SEER) program data.
The detailed data of patients with primary malignant brain tumors following an initial malignant tumor outside the central nervous system were extracted from SEER. Descriptive statistics were used to analyze patient demographic and clinical characteristics. We also extracted standardized incidence ratios (SIRs) stratified by age, race, sex, history of radiation or chemotherapy, histology findings, and primary cancer site.
We identified 5,212 patients diagnosed with primary malignant brain tumors following systemic malignancies. Most patients had prostate cancer, breast cancer, and skin melanoma as the primary cancer. The median duration between the first diagnosis of cancer and that of the subsequent malignant brain tumor was 53 months. Glioblastoma was the most common subsequent malignant brain tumor type. The prognosis after subsequent malignant brain tumor diagnosis was poor. The SIRs differed most by race, cancer site, and cancer type. Patients with acute lymphocytic leukemia had the highest risk of developing primary malignant brain tumors.
Our study provides a comprehensive analysis of clinical data and the SIRs of patients with primary malignant brain tumors afterward other systemic malignancies. Genetic relationships might play a key role in subsequent malignant brain tumor origin. Our data provide directions for future studies exploring the hidden associations between systemic malignancies and primary malignant brain tumors.
已有多项报告描述了不同癌症后继发的脑胶质瘤。我们基于美国监测、流行病学和最终结果（SEER）计划的数据，评估了美国系统性恶性肿瘤患者后继发原发性恶性脑肿瘤的患病率。
我们从 SEER 中提取了继发于中枢神经系统外初始恶性肿瘤的原发性恶性脑肿瘤患者的详细数据。采用描述性统计分析患者的人口统计学和临床特征。我们还提取了按年龄、种族、性别、放疗或化疗史、组织学发现和原发性癌症部位分层的标准化发病比（SIR）。
我们共确定了 5212 例继发于系统性恶性肿瘤的原发性恶性脑肿瘤患者。大多数患者的首发癌症为前列腺癌、乳腺癌和皮肤黑色素瘤。首次诊断癌症与随后发生恶性脑肿瘤之间的中位时间间隔为 53 个月。胶质母细胞瘤是最常见的继发恶性脑肿瘤类型。诊断后继发性恶性脑肿瘤后的预后较差。SIR 主要受种族、癌症部位和癌症类型的影响最大。急性淋巴细胞白血病患者发生原发性恶性脑肿瘤的风险最高。
本研究提供了对继发于其他系统性恶性肿瘤的原发性恶性脑肿瘤患者临床数据和 SIR 的综合分析。遗传关系可能在继发恶性脑肿瘤的起源中发挥关键作用。我们的数据为未来探索系统性恶性肿瘤与原发性恶性脑肿瘤之间潜在关联的研究提供了方向。
