嗜铬粒蛋白 A 衍生肽胰淀素的免疫调节功能。
The immunomodulatory functions of chromogranin A-derived peptide pancreastatin.
机构信息
Department of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, the Netherlands.
VA San Diego Healthcare System, San Diego, CA, USA; Department of Medicine, University of California San Diego, La Jolla, CA, USA.
出版信息
Peptides. 2022 Dec;158:170893. doi: 10.1016/j.peptides.2022.170893. Epub 2022 Oct 13.
Chromogranin A (CgA) is a 439 amino acid protein secreted by neuroendocrine cells. Proteolytic processing of CgA results in the production of different bioactive peptides. These peptides have been associated with inflammatory bowel disease, diabetes, and cancer. One of the chromogranin A-derived peptides is ∼52 amino acid long Pancreastatin (PST: human (h)CgA, murine (m)CgA). PST is a glycogenolytic peptide that inhibits glucose-induced insulin secretion from pancreatic islet β-cells. In addition to this metabolic role, evidence is emerging that PST also has inflammatory properties. This review will discuss the immunomodulatory properties of PST and its possible mechanisms of action and regulation. Moreover, this review will discuss the potential translation to humans and how PST may be an interesting therapeutic target for treating inflammatory diseases.
嗜铬粒蛋白 A（CgA）是一种由神经内分泌细胞分泌的 439 个氨基酸的蛋白质。CgA 的蛋白水解处理导致产生不同的生物活性肽。这些肽与炎症性肠病、糖尿病和癌症有关。CgA 衍生的肽之一约为 52 个氨基酸长的 Pancreastatin（PST：人（h）CgA，鼠（m）CgA）。PST 是一种糖原分解肽，可抑制胰岛β细胞葡萄糖诱导的胰岛素分泌。除了这种代谢作用外，越来越多的证据表明 PST 还具有炎症特性。这篇综述将讨论 PST 的免疫调节特性及其可能的作用机制和调节。此外，本文还将讨论其向人类的潜在转化以及 PST 如何成为治疗炎症性疾病的一个有趣的治疗靶点。
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