Sun Xiaojing, Shen Binyu, Yu Hui, Wu Wenhui, Sheng Ruilong, Fang Yiwen, Guo Ruihua
College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
CQM-Centro de Química da Madeira, Campus da Penteada, Universidade da Madeira, 9000-390 Funchal, Portugal.
Fitoterapia. 2022 Nov;163:105333. doi: 10.1016/j.fitote.2022.105333. Epub 2022 Oct 13.
Pentacyclic triterpenoids are important natural products widely presenting in nature with rich bioactivities. Tripterygium wilfordii Hook. f., a precious Chinese medicinal material, is used to cure rheumatoid arthritis, nephrotic syndrome, systemic lupus erythematosus. Triterpenoids are one of the important active components of Tripterygium wilfordii Hook. f. Demethylzeylasteral extracted from Tripterygium wilfordii Hook. f. had numerous pharmacological effects, including anticancer, anti-inflammatory, immune suppression, anti-fertility, antivirus, antimicrobial. In this paper, we summarized comprehensively pharmacological activities of demethylzeylasteral for potential application as a therapeutic agent.
五环三萜类化合物是自然界中广泛存在的重要天然产物，具有丰富的生物活性。雷公藤，一种珍贵的中药材，用于治疗类风湿性关节炎、肾病综合征、系统性红斑狼疮。三萜类化合物是雷公藤的重要活性成分之一。从雷公藤中提取的去甲基泽拉斯特醇具有多种药理作用，包括抗癌、抗炎、免疫抑制、抗生育、抗病毒、抗菌。在本文中，我们全面总结了去甲基泽拉斯特醇作为治疗剂的潜在应用的药理活性。
