Ksander G A, Vistnes L M, Fogarty D C
Plast Reconstr Surg. 1978 Dec;62(6):873-84. doi: 10.1097/00006534-197812000-00008.
Soft-gel miniprostheses of silicone were implanted subcutaneously into 75 male rats. Groups of prostheses were preinjected with saline, a commercial form of triamcinolone acetonide, or a suspension of crystalline triamcinolone acetonide. The softness of the prosthesis mound later was measured objectively, and the capsules surrounding the implants were analyzed by histology, SEM, and chemistry, at various intervals up to 120 days after implantation. The control implants developed a normal laminar capsule. With an incidence increasing up to 100 percent at 120 days, the steroid-treated implants were surrounded by capsules lacking an inner membrane. The inner membrane of the laminar capsule had a high protein content (relative to normal tissue) and a relatively reduced collagen content, while the diffuse capsule resulting from the TA treatment had a high protein content and a high collagen content (about the same as normal tissue). No differences were found in the softness of the mounds of the implanted prostheses. The effect of the TA treatment was explained on the basis of its collagenolytic effect, which could gradually erode the normal capsule membrane. Capsule firmness could not be related to the architecture or the protein or collagen content in our findings. We hypothesize that normal capsule firmness may be related to the amount and kind of interconnection between the loose outer zone of connective tissue and the surrounding tissue.
将硅酮软凝胶微型假体皮下植入75只雄性大鼠体内。假体组预先注射生理盐水、曲安奈德的市售制剂或曲安奈德结晶悬液。在植入后长达120天的不同时间间隔，客观测量假体隆起的柔软度，并通过组织学、扫描电子显微镜和化学分析植入物周围的包膜。对照植入物形成正常的层状包膜。在120天时，类固醇处理的植入物被缺乏内膜的包膜包围的发生率高达100%。层状包膜的内膜蛋白质含量高（相对于正常组织），胶原蛋白含量相对减少，而曲安奈德处理导致的弥漫性包膜蛋白质含量高，胶原蛋白含量也高（与正常组织大致相同）。植入假体隆起的柔软度未发现差异。基于曲安奈德的胶原溶解作用解释了其治疗效果，该作用可逐渐侵蚀正常的包膜。在我们的研究结果中，包膜硬度与结构或蛋白质或胶原蛋白含量无关。我们推测正常包膜硬度可能与结缔组织疏松外层区域与周围组织之间的连接数量和种类有关。
