Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Building 75, Cnr College Rd & Cooper Rd, St Lucia, QLD 4072, Australia.
Institute for Glycomics, Griffith University, Parklands Dr Southport, Gold Coast, QLD 4222, Australia.
Trends Immunol. 2022 Nov;43(11):864-867. doi: 10.1016/j.it.2022.09.004. Epub 2022 Oct 13.
Recent evidence suggests that cancer cell-derived extracellular vesicles might facilitate immunoevasion. Glycans are known to play a key role in immunomodulation, especially when tethered to biological membranes. However, the extracellular vesicle glycocode in cancer immunoevasion remains a largely unexplored area with promising potential for new putative diagnostic and therapeutic applications.
最近的证据表明，癌细胞衍生的细胞外囊泡可能有助于免疫逃逸。众所周知，聚糖在免疫调节中起着关键作用，尤其是与生物膜结合时。然而，癌症免疫逃逸中外泌体糖组学是一个很大程度上尚未开发的领域，具有新的潜在诊断和治疗应用的广阔前景。
