聚焦细胞外囊泡：基于细胞外囊泡的治疗系统的开发。
Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems.
机构信息
Department of Molecular Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan.
Cellular Stress and Ageing Program, Bionanoscience and Bio-Imaging Program, Bio & Nano-Solutions, D-33647 Bielefeld, Germany.
出版信息
Int J Mol Sci. 2016 Feb 6;17(2):172. doi: 10.3390/ijms17020172.
Many types of cells release phospholipid membrane vesicles thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents. Extracellular vesicles (EVs) carry various proteins, messenger RNAs (mRNAs), and microRNAs (miRNAs), like a "message in a bottle" to cells in remote locations. The encapsulated molecules are protected from multiple types of degradative enzymes in body fluids, making EVs ideal for delivering drugs. This review presents an overview of the potential roles of EVs as natural drugs and novel drug-delivery systems.
许多类型的细胞释放磷脂膜囊泡，这些囊泡被认为在细胞间通讯、抗原呈递和传染性因子的传播中发挥关键作用。细胞外囊泡 (EVs) 携带各种蛋白质、信使 RNA (mRNA) 和 microRNA (miRNA)，就像“瓶子里的信息”一样，传递给远处的细胞。囊封的分子受到体液中多种类型的降解酶的保护，这使得 EVs 成为理想的药物输送载体。本文综述了 EVs 作为天然药物和新型药物输送系统的潜在作用。
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