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GIMAP4 的预后价值及其在促进肺腺癌肿瘤微环境中免疫细胞浸润中的作用。

Prognostic Value of GIMAP4 and Its Role in Promoting Immune Cell Infiltration into Tumor Microenvironment of Lung Adenocarcinoma.

机构信息

Department of Cardiothoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214023, China.

The Pq Laboratory of BiomeDx/Rx, Department of Biomedical Engineering, Binghamton University, Binghamton, New York 13902, USA.

出版信息

Biomed Res Int. 2022 Oct 6;2022:7440189. doi: 10.1155/2022/7440189. eCollection 2022.

DOI:10.1155/2022/7440189
PMID:36246963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9560834/
Abstract

GIMAPs are recognized as an important regulator in the carcinogenesis and development of lung cancer, but the function of GIMAP4 in the tumor microenvironment (TME) of lung cancers is unclear. In this study, we investigated the expression and variation of GIMAP4 in lung adenocarcinoma (LUAD), to explore its association with infiltration of immune cells. The Cancer Genome Atlas (TCGA) data and Gene Expression Omnibus (GEO) data were analyzed. Infiltration of immune cells was identified with TIMER (Tumor Immune Estimation Resource) and TISIDB (an integrated repository portal for tumor-immune system interactions). GIMAP4 expression declined in non-small-cell lung cancer (NSCLC), correlated with a poor overall survival (OS) in LUAD, indicating that GIMAP4 was a promising prognostic biomarker in LUAD. GIMAP4 mutation frequency was 1.76% in TCGA cohort and was relevant to the expression of immune components. TIMER and CIBERSORT analysis further confirmed that high GIMAP4 expression possibly promoted immune cell infiltration into the TME, with low GIMAP4 impairing the efficacy of immunotherapies targeting common immune check point inhibitors (ICI). GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) analyses were performed to provide insights into biological processes involved in LUAD. GIMAP4 was expected to be a prognostic biomarker in LUAD and provides potential adjuvant or neoadjuvant therapeutic strategies for targeting ICIs.

摘要

GIMAPs 被认为是肺癌发生和发展中的一个重要调节因子，但 GIMAP4 在肺癌肿瘤微环境（TME）中的功能尚不清楚。在这项研究中，我们研究了 GIMAP4 在肺腺癌（LUAD）中的表达和变化，以探讨其与免疫细胞浸润的关系。分析了癌症基因组图谱（TCGA）数据和基因表达综合数据库（GEO）数据。使用 TIMER（肿瘤免疫估计资源）和 TISIDB（肿瘤-免疫系统相互作用的综合存储库门户）鉴定免疫细胞的浸润。非小细胞肺癌（NSCLC）中 GIMAP4 的表达下降，与 LUAD 的总生存期（OS）较差相关，表明 GIMAP4 是 LUAD 中有前途的预后生物标志物。在 TCGA 队列中，GIMAP4 突变频率为 1.76%，与免疫成分的表达相关。TIMER 和 CIBERSORT 分析进一步证实，高 GIMAP4 表达可能促进免疫细胞浸润 TME，而低 GIMAP4 则会降低针对常见免疫检查点抑制剂（ICI）的免疫疗法的疗效。进行了 GO（基因本体论）和 KEGG（京都基因与基因组百科全书）分析，以提供 LUAD 中涉及的生物学过程的见解。GIMAP4 有望成为 LUAD 的预后生物标志物，并为针对 ICI 的辅助或新辅助治疗策略提供了潜力。

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2
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3
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4
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