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Enabling Synthesis of ABBV-2222, A CFTR Corrector for the Treatment of Cystic Fibrosis.实现 ABBV-2222 的合成，一种用于囊性纤维化治疗的 CFTR 校正剂。
Org Lett. 2019 Jul 19;21(14):5725-5727. doi: 10.1021/acs.orglett.9b02099. Epub 2019 Jul 1.
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Total Synthesis of Caesalpinnone A and Caesalpinflavan B: Evolution of a Concise Strategy. Caesalpinnone A 和 Caesalpinflavan B 的全合成：简洁策略的演变。
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Formation of quaternary centres by copper catalysed asymmetric conjugate addition to β-substituted cyclopentenones with the aid of a quantitative structure-selectivity relationship.借助定量结构-选择性关系，通过铜催化的不对称共轭加成到β-取代环戊烯酮上形成季碳中心。
Chem Sci. 2018 Feb 5;9(9):2628-2632. doi: 10.1039/c7sc05304e. eCollection 2018 Mar 7.
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Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis.发现 4-[(2R,4R)-4-({[1-(2,2-二氟-1,3-苯并二氧杂环戊烯-5-基)环丙基]羰基}氨基)-7-(二氟甲氧基)-3,4-二氢-2H-色烯-2-基]苯甲酸（ABBV/GLPG-2222），一种用于治疗囊性纤维化的强效囊性纤维化跨膜电导调节剂（CFTR）校正剂。
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Enantioselective, Palladium-Catalyzed Conjugate Additions of Arylboronic Acids to Form Bis-benzylic Quaternary Stereocenters.手性钯催化的芳基硼酸与形成双苄基季碳立体中心的共轭加成反应。
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Acyclic quaternary centers from asymmetric conjugate addition of alkylzirconium reagents to linear trisubstituted enones.通过烷基锆试剂与线性三取代烯酮的不对称共轭加成反应构建无环季碳中心。
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Synthesis of diverse β-quaternary ketones via palladium-catalyzed asymmetric conjugate addition of arylboronic acids to cyclic enones.通过钯催化芳基硼酸对环状烯酮的不对称共轭加成合成多种β-季酮。
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Copper-catalyzed asymmetric conjugate addition of alkylzirconium reagents to cyclic enones to form quaternary centers.铜催化的手性烷基锆试剂与环状烯酮的不对称共轭加成反应，以形成季碳中心。
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