Zheng Huimin, Wang Tai, Shi Changhe, Fan Liyuan, Su Yun, Fan Yu, Li Xinwei, Yang Jing, Mao Chengyuan, Xu Yuming
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Front Neurol. 2022 Sep 30;13:993940. doi: 10.3389/fneur.2022.993940. eCollection 2022.
Regarding the complexity of Parkinson's disease (PD), the identification of reliable biomarkers is of great significance for improving the accuracy of diagnosis and monitoring disease progression. Recently, some studies suggested that serum proline-rich protein 14 (PRR14), vascular cell adhesion molecule-1 (VCAM-1), and soluble CD163 (sCD163) factors may be associated with PD, even as potential biomarkers. However, the role of these serum factors is still unclear.
This study aimed to explore the alterations of serum PRR14, VCAM-1, and sCD163 levels during PD progression, and their association with disease-related variables of PD.
We performed the assessment of scale tests and the detection of serum samples in patients with PD ( = 100) and healthy controls (HCs, = 100). Furthermore, we investigated the association between serum factors and sex, cognitive impairments, H&Y (Hohn and Yahr), age at onset (AAO), and other variables in patients with PD.
Patients with PD exhibited increased PRR14 and VCAM-1 serum levels compared with HCs. No significant differences were found in serum levels of sCD163. Subgroup analysis uncovered increased VCAM-1 in the female and male subgroups (PD and HCs). Among patients with PD, decreased PRR14 and increased VCAM-1 were associated with severer cognitive impairments and severer PD (H&Y), respectively. Bivariate correlation analysis revealed that there was a positive correlation between VCAM-1 and AAO.
Increased serum levels of PRR14 and VCAM-1 suggest that inflammation and defective autophagy may play vital roles in the pathogenesis of PD. However, the potential mechanisms remain to be elucidated.
鉴于帕金森病（PD）的复杂性，识别可靠的生物标志物对于提高诊断准确性和监测疾病进展具有重要意义。最近，一些研究表明，血清富含脯氨酸蛋白14（PRR14）、血管细胞黏附分子1（VCAM-1）和可溶性CD163（sCD163）因子可能与PD有关，甚至可能作为潜在的生物标志物。然而，这些血清因子的作用仍不明确。
本研究旨在探讨PD进展过程中血清PRR14、VCAM-1和sCD163水平的变化及其与PD疾病相关变量的关系。
我们对100例PD患者和100例健康对照（HCs）进行了量表测试评估和血清样本检测。此外，我们还研究了PD患者血清因子与性别、认知障碍、H&Y（霍恩和亚尔分级）、发病年龄（AAO）及其他变量之间的关系。
与HCs相比，PD患者的血清PRR14和VCAM-1水平升高。sCD163的血清水平未发现显著差异。亚组分析发现，女性和男性亚组（PD组和HCs组）的VCAM-1均升高。在PD患者中，PRR14降低和VCAM-1升高分别与更严重的认知障碍和更严重的PD（H&Y分级）相关。双变量相关性分析显示，VCAM-1与AAO之间存在正相关。
血清PRR14和VCAM-1水平升高表明炎症和自噬缺陷可能在PD发病机制中起重要作用。然而，其潜在机制仍有待阐明。
