Stĕpán J, Marek J, Havránek T, Dolezal V, Pacovský V
Clin Chim Acta. 1979 May 2;93(3):355-63. doi: 10.1016/0009-8981(79)90285-7.
In 37 patients with active acromegaly and in 15 patients with inactive acromegaly, activity of bone isoenzyme of serum alkaline phosphatase correlated (P less than 0.001) with serum concentration of immunoreactive growth hormone. By using stepwise regression analysis, the predication of serum growth hormone values based on serum levels of bone isoenzyme of serum alkaline phosphatase, gamma-glutamyl transferase and calcium in these patients with acromegaly was within 1 S.D. range in 37 patients and in only 2 patients was it out of 2 S.D. range. By using discriminant analysis, based on bone and liver isoenzymes of serum alaline phosphatase and urinary hydroxyproline excretion, 87%, 60% and 97% of the classification of patients with active and inactive acromegaly and healthy adults, respectively, was correct. The multivariate approach offers a quantitative appraisal of the biochemical parameters of peripheral growth hormone action used as an indicator of growth hormone concentration in patients with acromegaly.
在37例活动性肢端肥大症患者和15例非活动性肢端肥大症患者中，血清碱性磷酸酶骨同工酶的活性与免疫反应性生长激素的血清浓度相关（P<0.001）。通过逐步回归分析，基于血清碱性磷酸酶骨同工酶、γ-谷氨酰转移酶和钙的血清水平对这些肢端肥大症患者的血清生长激素值进行预测，在37例患者中，预测值在1个标准差范围内，只有2例患者超出2个标准差范围。通过判别分析，分别基于血清碱性磷酸酶的骨和肝同工酶以及尿羟脯氨酸排泄量，对活动性和非活动性肢端肥大症患者及健康成年人进行分类，正确分类率分别为87%、60%和97%。多变量方法为作为肢端肥大症患者生长激素浓度指标的外周生长激素作用的生化参数提供了定量评估。
