Chen Chau-Yin, Wang Sheng-Wen, Lai Chien-Hsiung, Chuang Hui-Chieh, Lin Ying-Yu, Wang Jin-Jhe
Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Taiwan J Ophthalmol. 2021 Jul 28;12(3):370-373. doi: 10.4103/tjo.tjo_26_21. eCollection 2022 Jul-Sep.
Ocular surface squamous neoplasia represents neoplastic epithelial abnormalities of conjunctiva and cornea, ranging from squamous dysplasia to invasive squamous cell carcinoma and is both sight- and life-threatening. Squamous spindle cell carcinoma (SSCC) of conjunctiva is a rare variant with distinct behavior which is thought to be more locally aggressive. We describe an 83-year-old woman with a progressively enlarging huge SSCC in her right eye over the past 2 years. The tumor bulged out with local invasion into intraocular and orbital cavities. Wide excision of the tumor with frozen section control was performed. After surgery, topical 0.03% mitomycin C was given as adjuvant therapy. At 40-month follow-up, the lesion site showed no evidence of local recurrence. This case provides a valuable and complete experience of the clinical presentation for the progression and treatment of this rare disease.
眼表鳞状上皮肿瘤代表结膜和角膜的肿瘤性上皮异常，范围从鳞状上皮发育异常到浸润性鳞状细胞癌，对视力和生命均构成威胁。结膜鳞状梭形细胞癌（SSCC）是一种罕见的变异型，具有独特的行为，被认为更具局部侵袭性。我们描述了一位83岁女性，在过去2年中右眼患有逐渐增大的巨大SSCC。肿瘤向外突出并局部侵犯眼内和眼眶腔。进行了肿瘤广泛切除并进行冰冻切片控制。术后给予局部0.03%丝裂霉素C作为辅助治疗。在40个月的随访中，病变部位未显示局部复发迹象。该病例为这种罕见疾病的进展和治疗提供了宝贵且完整的临床表现经验。
