Department of Ophthalmology and Visual Sciences, Toronto Western Hospital, University of Toronto, Ontario, Canada.
Eye Contact Lens. 2012 Mar;38(2):133-6. doi: 10.1097/ICL.0b013e318235c4d3.
Conjunctival squamous dysplasia can often be confused with pterygium and pinguecula. Incomplete excision of dysplastic tissue can lead to recurrence and rarely intraocular invasion. This study describes two cases in which invasive squamous cell carcinoma (SCC) of the conjunctiva was originally partially resected as pterygium and eventually required enucleation for intraocular invasion.
In this clinicopathologic small case series, two cases of intraocular SCC managed at a single tertiary ocular oncology institution are described. Clinical features, pathologic characteristics, and relevant imaging are described.
In both cases, incomplete excision of conjunctival SCC was followed by rapid regrowth of the conjunctival lesion and signs of intraocular inflammation. An intraocular mass within the substance of the ciliary body was identified using ultrasound biomicroscopy in both the cases. Enucleation was performed. Pathologic features were typical to SCC.
Intraocular spread on conjunctival SCC occurs only rarely but tends to follow recurrence of the conjunctival lesion after attempted excision. Modes of invasion may include direct invasion through sclera, along the tract of the anterior ciliary vessels, or inoculation through intraocular surgery incision.
结膜鳞状上皮异型增生常与翼状胬肉和结膜变性混淆。异型组织切除不完全可导致复发，且罕见情况下可向眼内侵犯。本研究描述了两例最初部分切除为翼状胬肉的结膜侵袭性鳞状细胞癌（SCC），最终因眼内侵犯而需要眼球摘除。
本临床病理小病例系列研究描述了在一家三级眼科肿瘤专科机构治疗的两例眼内 SCC。描述了临床特征、病理特征和相关影像学表现。
在这两例中，结膜 SCC 的不完全切除后，结膜病变迅速复发，并出现眼内炎症迹象。在这两例中，均通过超声生物显微镜发现睫状体实质内有眼内肿块。进行了眼球摘除术。病理特征符合 SCC。
结膜 SCC 的眼内播散很少见，但往往在试图切除后结膜病变复发后发生。侵犯方式可能包括通过巩膜直接侵犯、沿着前睫状血管途径侵犯或通过眼内手术切口接种。
