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乳腺腺癌手术后放疗后发生的乳腺皮肤血管肉瘤

[Cutaneous angiosarcoma of the breast following surgery and irradiation of breast adenocarcinoma].

作者信息

Body G, Sauvanet E, Calais G, Fignon A, Fetissof F, Lansac J

出版信息

J Gynecol Obstet Biol Reprod (Paris). 1987;16(4):479-83.

PMID:3624820
Abstract

We are reporting a localised skin angiosarcoma of the breast. As far as we can tell this is only the fourth time this condition has been published. The tumour appeared 6 years after a conservative lumpectomy with removal of lymphatics and follow-up radiotherapy had been carried out for an adenocarcinoma of the breast. This tumour was characterised by the presence of several round blue-coloured nodules in the skin with some inflammation surrounding them. The glandular tissue underneath was normal, as was the opposite breast, and there was no spread. The patient was pyrexial and a syndrome of inflammation persisted until the tumour had been removed by a simple mastectomy. We have discussed the clinical and histological aspects of this case and compared them with those found in the literature. Differential diagnosis with in particular Stewart-Treves syndrome has been emphasized. The treatment consists in wide excision and sometimes followed by radiotherapy or chemotherapy. The prognosis is very poor, survival never having been more than 22 months. Finally the role of irradiation in the causation of this tumour has been discussed. (Our patient is alive after 2 years without any sign of a recurrence).

摘要

我们报告了一例乳腺局限性皮肤血管肉瘤。据我们所知,这是该病症第四次被发表。该肿瘤在因乳腺腺癌行保守性肿块切除术并切除淋巴管及后续放疗6年后出现。此肿瘤的特征是皮肤出现数个圆形蓝色结节,周围有一些炎症。其下方的腺组织正常,对侧乳房也正常,且无扩散。患者发热,炎症综合征持续存在,直至通过单纯乳房切除术切除肿瘤。我们讨论了该病例的临床和组织学方面,并将其与文献中的情况进行了比较。特别强调了与斯图尔特 - 特里夫斯综合征的鉴别诊断。治疗方法包括广泛切除,有时随后进行放疗或化疗。预后非常差,生存期从未超过22个月。最后讨论了放疗在该肿瘤病因中的作用。(我们的患者在2年后仍然存活,没有任何复发迹象)

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