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癌症患者慢性术后疼痛的患病率:一项横断面研究。

Prevalence of Chronic Postsurgical Pain among Cancer Patients: A Cross-Sectional Study.

作者信息

Ramadan Mahmoud I, Khudair Hussein Y Abu, Obaid Abdullah T, Yousef Ola A, Sammour Raja A

机构信息

King Hussein Cancer Center, Amman, Jordan.

King Hussein Cancer Center, Amman 11941, Jordan.

出版信息

Anesth Essays Res. 2022 Jan-Mar;16(1):71-79. doi: 10.4103/aer.aer_24_22. Epub 2022 Jun 27.

DOI:10.4103/aer.aer_24_22
PMID:36249138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9558672/
Abstract

BACKGROUND

Cancer patients accept surgeries as part of their treatment. They may not be aware of the possibility of surgical pain persisting long after the surgery. Understanding chronic postsurgical pain is essential for effective pain management.

AIMS

We aimed to assess the prevalence of chronic postsurgical pain in cancer patients and the associated symptom burden.

SETTINGS AND DESIGN

This study was carried out at a tertiary cancer center. It was a cross-sectional study.

MATERIALS AND METHODS

Participants who underwent surgeries were asked to provide feedback on the MD Anderson Symptom Inventory at 3 months.

STATISTICAL ANALYSIS USED

Descriptive statistics were used. Statistical tests included Kruskal-Wallis test, Chi-square test, Fisher's exact test, and Spearman's correlation. Logistic regression was used to assess the influence of variables on the presence or absence of chronic postsurgical pain.

RESULTS

Nine hundred and eighteen participants completed the study. Ninety-two percent ( = 840) were asymptomatic. Eight percent ( = 78) had postsurgical pain. Chronic postsurgical pain was influenced by the type of surgery ( = 0.01), specifically orthopedic and thoracic surgeries. Patients who receive epidurals are three times less likely to continue to have pain at 3 months.

CONCLUSIONS

The prevalence of chronic postsurgical pain at 3 months in this study is lower than the rates in the literature. It is still associated with symptom burden that interferes with daily life. The risk of developing chronic postsurgical pain increases with thoracic and orthopedic surgeries. The risk may be lowered with epidural analgesia.

摘要

背景

癌症患者接受手术作为其治疗的一部分。他们可能没有意识到手术后手术疼痛持续很长时间的可能性。了解慢性术后疼痛对于有效的疼痛管理至关重要。

目的

我们旨在评估癌症患者慢性术后疼痛的患病率及相关的症状负担。

设置与设计

本研究在一家三级癌症中心进行。这是一项横断面研究。

材料与方法

接受手术的参与者被要求在3个月时就MD安德森症状量表提供反馈。

所用统计分析

采用描述性统计。统计检验包括Kruskal-Wallis检验、卡方检验、Fisher精确检验和Spearman相关性分析。采用逻辑回归评估变量对慢性术后疼痛存在与否的影响。

结果

918名参与者完成了研究。92%(n = 840)无症状。8%(n = 78)有术后疼痛。慢性术后疼痛受手术类型影响(P = 0.01),特别是骨科和胸科手术。接受硬膜外麻醉的患者在3个月时持续疼痛的可能性降低三倍。

结论

本研究中3个月时慢性术后疼痛的患病率低于文献报道的比率。它仍与干扰日常生活的症状负担相关。胸科和骨科手术会增加发生慢性术后疼痛的风险。硬膜外镇痛可能会降低这种风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ae4/9558672/e4abfc6ef945/AER-16-71-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ae4/9558672/5d03e78986c8/AER-16-71-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ae4/9558672/ff7fd5cdc90b/AER-16-71-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ae4/9558672/1a526679efda/AER-16-71-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ae4/9558672/4f59d4538620/AER-16-71-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ae4/9558672/0356709fde4c/AER-16-71-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ae4/9558672/e4abfc6ef945/AER-16-71-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ae4/9558672/5d03e78986c8/AER-16-71-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ae4/9558672/ff7fd5cdc90b/AER-16-71-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ae4/9558672/1a526679efda/AER-16-71-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ae4/9558672/4f59d4538620/AER-16-71-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ae4/9558672/0356709fde4c/AER-16-71-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ae4/9558672/e4abfc6ef945/AER-16-71-g006.jpg

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本文引用的文献

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Pre-emptive epidural analgesia for acute and chronic post-thoracotomy pain in adults: a systematic review and meta-analysis.成人开胸术后急性和慢性疼痛的预防性硬膜外镇痛:系统评价和荟萃分析。
Reg Anesth Pain Med. 2020 Dec;45(12):1006-1016. doi: 10.1136/rapm-2020-101708. Epub 2020 Oct 14.
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Breast Cancer Care in Jordan.约旦的乳腺癌护理
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The Global Burden of Cancer Pain.全球癌症疼痛负担
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The IASP classification of chronic pain for ICD-11: chronic postsurgical or posttraumatic pain.国际疼痛学会(IASP)ICD-11 慢性疼痛分类:慢性手术后或创伤后疼痛。
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Persistent Post-Mastectomy Pain: Risk Factors and Current Approaches to Treatment.持续性乳房切除术后疼痛:风险因素和当前治疗方法。
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Eur J Oncol Nurs. 2018 Apr;33:56-61. doi: 10.1016/j.ejon.2018.01.009. Epub 2018 Feb 3.
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A multicenter study of attitudinal barriers to cancer pain management.一项关于癌症疼痛管理态度障碍的多中心研究。
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Pain prevalence in cancer patients: status quo or opportunities for improvement?癌症患者的疼痛患病率:现状还是改善机会?
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