Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Translational Laboratory of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Public Health. 2022 Sep 28;10:993377. doi: 10.3389/fpubh.2022.993377. eCollection 2022.
This study performed a follow-up investigation of parasitic infections and the evolution of the infection spectra in Shanghai and its surrounding areas in Eastern China. The current study was conducted in the Shanghai Ruijin Hospital, a tertiary hospital affiliated with Shanghai Jiao Tong University School of Medicine.
This retrospective investigation reviewed a total of 412 parasitic infections in patients admitted to the Department of Infectious Diseases, Ruijin Hospital from January 1, 2010 to July 31, 2022. Detailed information for these patients was retrieved from the Electronic Medical Record System. Analysis was performed using GraphPad Prism 5.0 and SPSS Statistics 26.
Overall, 17 species of parasites were detected from the 412 admissions. Over the 13 years, the number of patients peaked in 2021 and food-born parasites (FBPs) were the primary species. During the most recent 5 years, , replacing , has become the primary parasite detected among the patients, consistent with the observation that eating uncooked fish has turned into the most common route of transmission. infections declined with age, but increased with age. The periods from the onset of symptoms to definite diagnosis for some patients infected with , and were more than 6 months. Interestingly, eosinophilia was only detected in 51.83% of parasite-infected patients. In addition, superinfections of parasites were common in our study.
Our study demonstrates the transitional change in the prevalence of parasitic infection over the latest 13 years in a single center in Eastern China. The incidence of parasitic infections peaked in 2021, and the dominant parasitic species switched from a soil origin to foodborne. The direction for the diagnosis and prevention of parasitic infection among different age groups should alter according to age. It is difficult to diagnose parasitic infections and superinfections that occur in some patients. Thus, more sensitive and efficient detection methods should be developed. In addition, although eosinophilia and elevated IgE are still reliable indicators for initiating screening of parasitic infection, the development of novel parasitic diagnostic kits is still in urgent need for occult infection.
本研究对中国东部上海及其周边地区的寄生虫感染和感染谱的演变进行了随访调查。本研究在上海交通大学医学院附属瑞金医院传染病科进行。
本回顾性调查共回顾了 2010 年 1 月 1 日至 2022 年 7 月 31 日期间因寄生虫感染入住瑞金医院感染科的 412 例患者。从电子病历系统中检索这些患者的详细信息。使用 GraphPad Prism 5.0 和 SPSS Statistics 26 进行分析。
总体而言，从 412 例住院患者中检测到 17 种寄生虫。在这 13 年中，患者人数在 2021 年达到峰值，食源性寄生虫（FBPs）是主要的寄生虫种类。在最近的 5 年中，取代了，成为患者中主要检测到的寄生虫，这与食用生鱼成为最常见的传播途径的观察结果一致。随着年龄的增长，感染率下降，但感染率随着年龄的增长而增加。一些感染、和的患者从出现症状到明确诊断的时间超过 6 个月。有趣的是，只有 51.83%的寄生虫感染患者出现嗜酸性粒细胞增多。此外，在我们的研究中，寄生虫的混合感染很常见。
本研究表明，在中国东部的一个单一中心，过去 13 年来寄生虫感染的流行情况发生了转变。寄生虫感染的发病率在 2021 年达到峰值，优势寄生虫种从土壤来源转变为食源性。不同年龄组寄生虫感染和混合感染的诊断和预防方向应根据年龄进行调整。一些患者的寄生虫感染和混合感染诊断困难。因此，应开发更敏感和有效的检测方法。此外，虽然嗜酸性粒细胞增多和 IgE 升高仍然是寄生虫感染筛查的可靠指标，但新型寄生虫诊断试剂盒的开发仍亟待解决隐匿性感染问题。
