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藏红花的神经精神作用：关于其在精神和神经疾病临床疗效的系统评价与荟萃分析综述

The neuropsychotropic effects of L. (saffron): an overview of systematic reviews and meta-analyses investigating its clinical efficacy in psychiatric and neurological disorders.

作者信息

Shamabadi Ahmad, Hasanzadeh Alireza, Akhondzadeh Shahin

机构信息

School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Avicenna J Phytomed. 2022 Sep-Oct;12(5):475-488. doi: 10.22038/AJP.2021.19300.

DOI:10.22038/AJP.2021.19300
PMID:36249453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9516399/
Abstract

OBJECTIVE

Saffron is a spice derived from the L. with antioxidant, anti-inflammatory, and neuroprotective effects. This study aims to systematically review the systematic reviews (SRs) investigating the clinical neuropsychotropic effects of saffron.

MATERIALS AND METHODS

The protocol of this SR was registered in PROSPERO (CRD42021268446). Scopus, ISI Web of Science, Embase, MEDLINE, PubMed, CINAHL, Cochrane Library, Google Scholar, and PROSPERO were searched up to June 6, 2021, to find SRs investigating the neuropsychotropic effects of saffron. The primary outcome was a report on whether or not saffron was effective in each study. AMSTAR was checked for the included reviews.

RESULTS

Twenty-three studies were reviewed with a mean AMSTAR score of 6.08 (ranging from 1 to 10). Thirteen SRs investigated the effects of saffron on depression. Six of the SRs studied its impact on sexual dysfunction. Each of the anxiety and cognitive disorders was discussed in three distinct reviews. Furthermore, possible effects of saffron on some other disorders, like premenstrual syndrome, postpartum depression, sleep disorders, and snacking behavior, have been reported.

CONCLUSION

Saffron is beneficial, safe, and tolerable in treating the mentioned neurological and psychiatric disorders. Further high-quality, large-scale studies are recommended to rectify the shortcomings.

摘要

目的

藏红花是一种从番红花属植物中提取的香料，具有抗氧化、抗炎和神经保护作用。本研究旨在系统评价关于藏红花临床神经精神作用的系统评价（SRs）。

材料与方法

本SR的方案已在国际前瞻性系统评价注册库（PROSPERO，注册号：CRD42021268446）登记。检索了Scopus、科学引文索引（ISI Web of Science）、Embase、医学文献数据库（MEDLINE）、美国国立医学图书馆生物医学期刊数据库（PubMed）、护理及健康照护领域数据库（CINAHL）、考克兰图书馆、谷歌学术和PROSPERO，检索截至2021年6月6日，以查找研究藏红花神经精神作用的SRs。主要结局是各研究中关于藏红花是否有效的报告。对纳入的综述进行了测量工具质量评价的AMSTAR量表检查。

结果

共纳入23项研究，AMSTAR量表平均得分为6.08（范围为1至10）。13项SRs研究了藏红花对抑郁症的影响。6项SRs研究了其对性功能障碍的影响。焦虑症和认知障碍分别在3项不同的综述中进行了讨论。此外，还报告了藏红花对其他一些疾病的可能影响，如经前综合征、产后抑郁症、睡眠障碍和零食行为。

结论

藏红花在治疗上述神经和精神疾病方面有益、安全且耐受性良好。建议开展进一步的高质量、大规模研究以弥补不足之处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa10/9516399/441fa9bc8646/AJP-12-475-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa10/9516399/441fa9bc8646/AJP-12-475-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa10/9516399/441fa9bc8646/AJP-12-475-g001.jpg

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Saffron for mild cognitive impairment and dementia: a systematic review and meta-analysis of randomised clinical trials.藏红花治疗轻度认知障碍和痴呆症的系统评价和荟萃分析：随机临床试验。
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Neurol Sci. 2020 Oct;41(10):2747-2754. doi: 10.1007/s10072-020-04427-0. Epub 2020 May 23.
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The effects of saffron (Crocus sativus L.) on mental health parameters and C-reactive protein: A meta-analysis of randomized clinical trials.藏红花（Crocus sativus L.）对心理健康参数和 C 反应蛋白的影响：随机临床试验的荟萃分析。
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