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青少年患者中与母亲新冠病毒感染相关的新生儿结局

Neonatal Outcome Associated With Maternal COVID-19 Infection in Adolescent Patients.

作者信息

Uzunov Ana V, Secara Diana C, Cirstoiu Monica M

机构信息

Obstetrics and Gynaecology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, ROU.

Obstetrics and Gynaecology, University Emergency Hospital, "Carol Davila" University of Medicine and Pharmacy, Bucharest, ROU.

出版信息

Cureus. 2022 Sep 10;14(9):e29006. doi: 10.7759/cureus.29006. eCollection 2022 Sep.

Abstract

Background Coronavirus disease 2019 (COVID-19) infection during pregnancy has been associated with high rates of preeclampsia, stillbirth, and preterm birth. Adolescent pregnancy has also been associated with various adverse maternal and neonatal outcomes, including preeclampsia, stillbirth, preterm birth, congenital anomalies, and low birth weight. Therefore, this study aimed to determine whether COVID-19 infection associated with adolescent pregnancy represents an additional risk factor. Methods We performed a study that included 17 adolescent COVID-19- positive patients, who delivered in the Department of Obstetrics and Gynecology of University Emergency Hospital, Bucharest, between 01.04.2020 and 15.04.2022, and a control group of 17 patients who were COVID-19-negative and delivered in the same period in the same unit. In the control group, additional risk factors that could affect neonatal outcomes were excluded. The COVID-19 infection was confirmed using a polymerase chain reaction (PCR) test. The analysis of neonatal outcomes included preterm birth, low birth weight, stillbirth, congenital anomalies, and Apgar score calculated at one minute. Results The data from this study showed that COVID-19 infection does not influence the newborn's weight or Apgar score in adolescent patients. Also, in our study, COVID-19 infection was not statistically significant according to preterm delivery in adolescents. Conclusion Adolescent pregnancy represents an important health problem associated with a high risk of maternal and neonatal complications. However, COVID-19 infection does not influence neonatal outcomes in this population.

摘要

背景

2019年冠状病毒病(COVID-19)感染在孕期与子痫前期、死产和早产的高发生率相关。青少年怀孕也与各种不良的孕产妇和新生儿结局相关,包括子痫前期、死产、早产、先天性异常和低出生体重。因此,本研究旨在确定与青少年怀孕相关的COVID-19感染是否代表一个额外的风险因素。方法:我们进行了一项研究,纳入了17例COVID-19检测呈阳性的青少年患者,他们于2020年4月1日至2022年4月15日在布加勒斯特大学急诊医院妇产科分娩,以及一个由17例COVID-19检测呈阴性且同期在同一科室分娩的患者组成的对照组。在对照组中,排除了可能影响新生儿结局的其他风险因素。COVID-19感染通过聚合酶链反应(PCR)检测确诊。对新生儿结局的分析包括早产、低出生体重、死产、先天性异常以及出生后1分钟时计算的阿氏评分。结果:本研究的数据显示,COVID-19感染不会影响青少年患者新生儿的体重或阿氏评分。此外,在我们的研究中,根据青少年早产情况,COVID-19感染无统计学意义。结论:青少年怀孕是一个与孕产妇和新生儿并发症高风险相关的重要健康问题。然而,COVID-19感染不会影响该人群的新生儿结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/218e/9549998/1e63c5ce2d6f/cureus-0014-00000029006-i01.jpg

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