Kathane Piyush U, Vagha Keta
Community Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Pediatrics, Acharya Vinoba Bhave Rural Hospital, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Cureus. 2022 Sep 11;14(9):e29061. doi: 10.7759/cureus.29061. eCollection 2022 Sep.
Several new diagnostic and management challenges have evolved as a result of limited knowledge about the incidence of multisystem inflammatory syndrome in children (MISC) and its natural history which is caused by coronavirus disease 2019 (COVID-19) infection. There are no data on the long-term outcomes of the illness and MISC. A 12-year-old female child with no significant history was rushed to a emergency room with complaints of rashes all over her body for the past seven days, fever for the past five days, and altered sensorium for the last one day. The child tested negative for COVID-19 at first and then was found to be antibody positive for COVID-19. The child showed symptoms of the multisystem inflammatory syndrome, which involved the main alteration in liver functioning. This case is suggestive of how the COVID-19 virus causes alteration in liver functioning and its inflammation, including inflammation of other organs, which is called MISC.
由于对儿童多系统炎症综合征(MISC)的发病率及其由2019冠状病毒病(COVID-19)感染引起的自然史了解有限,出现了一些新的诊断和管理挑战。目前尚无关于该疾病和MISC长期预后的数据。一名12岁无重要病史的女童因过去七天全身皮疹、过去五天发热、最后一天意识改变被紧急送往急诊室。该儿童最初COVID-19检测呈阴性,随后被发现COVID-19抗体呈阳性。该儿童出现了多系统炎症综合征的症状,其中涉及肝功能的主要改变。该病例提示了COVID-19病毒如何导致肝功能改变及其炎症,包括其他器官的炎症,即MISC。