Li Qiang, Gong Peijun, Ho Phuoc Hao, Kennedy Brendan F, Mackey David A, Chen Fred K, Charng Jason
Centre of Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, Perth, Australia.
BRITElab, Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, The University of Western Australia, Perth, WA, Australia.
Ophthalmol Sci. 2022 Mar 1;2(2):100134. doi: 10.1016/j.xops.2022.100134. eCollection 2022 Jun.
To examine the distribution of foveal avascular zone (FAZ) parameters, with and without correction for lateral magnification, in a large cohort of healthy young adults.
Cross-sectional, observational cohort study.
A total of 504 healthy adults, 27 to 30 years of age.
Participants underwent a comprehensive ophthalmic examination including axial length measurement and OCT angiography (OCTA) imaging of the macula. OCT angiography images of combined superficial and deep retinal vessel plexuses were processed via a custom software to extract foveal avascular zone area (FAZA) and foveal density-300 (FD-300), the vessel density in a 300-μm wide annulus surrounding the FAZ, with and without correction for lateral magnification. Bland-Altman analyses were performed to examine the effect of lateral magnification on FAZA and FD-300, as well as to evaluate the interocular agreement in both parameters. Linear mixed-effects models were used to examine the relationship between retinal thicknesses and OCTA parameters.
The FAZA and FD-300, corrected for lateral magnification.
The mean (standard deviation [SD]) of laterally corrected FAZA and FD-300 was 0.22 mm (0.10 mm) and 51.9% (3.2%), respectively. Relative to uncorrected data, 55.6% of corrected FAZA showed a relative change > 5%, whereas all FD-300 changes were within 5%. There was good interocular symmetry (mean right eye-left eye difference, 95% limits of agreement [LoA]) in both FAZA (0.006 mm, -0.05 mm, to 0.07 mm) and FD-300 (-0.05%, -5.39%, to 5.30%). There were significant negative associations between central retinal thickness and FAZA (β = -0.0029), as well as between central retinal thickness and FD-300 (β = -0.044), with the relationships driven by inner, not outer, retina.
We reported lateral magnification adjusted normative values for FAZA and FD-300 in a large cohort of young, healthy eyes. Clinicians should strongly consider accounting for lateral magnification when evaluating FAZA. Good interocular agreement in FAZA and FD-300 suggests the contralateral eye can be used as control data.
在一大群健康的年轻成年人中，研究有无横向放大率校正情况下的黄斑无血管区（FAZ）参数分布。
横断面观察性队列研究。
共504名年龄在27至30岁的健康成年人。
参与者接受了全面的眼科检查，包括眼轴长度测量和黄斑区的光学相干断层扫描血管造影（OCTA）成像。通过定制软件处理视网膜浅、深血管丛联合的OCTA图像，以提取黄斑无血管区面积（FAZA）和黄斑密度-300（FD-300），即围绕FAZ的300μm宽环带内的血管密度，有无横向放大率校正。进行Bland-Altman分析以检查横向放大率对FAZA和FD-300的影响，以及评估这两个参数的双眼一致性。使用线性混合效应模型检查视网膜厚度与OCTA参数之间的关系。
经横向放大率校正后的FAZA和FD-300。
经横向校正后的FAZA和FD-300的平均值（标准差[SD]）分别为0.22mm（0.10mm）和51.9%（3.2%）。相对于未校正的数据，55.6%的校正后FAZA显示相对变化>5%，而所有FD-300的变化都在5%以内。FAZA（0.006mm，-0.05mm至0.07mm）和FD-300（-0.05%，-5.39%至5.30%）在双眼间均具有良好的对称性（平均右眼-左眼差值，95%一致性界限[LoA]）。中央视网膜厚度与FAZA（β=-0.0029）以及中央视网膜厚度与FD-300（β=-0.044）之间存在显著的负相关，这些关系由视网膜内层而非外层驱动。
我们报告了一大群年轻健康眼睛中经横向放大率调整后的FAZA和FD-300的标准值。临床医生在评估FAZA时应强烈考虑横向放大率。FAZA和FD-300在双眼间的良好一致性表明对侧眼可作为对照数据。
