Sawaguchi Shota, Terao Nobuhiro, Imanaga Naoya, Wakugawa Sorako, Tamashiro Tamaki, Yamauchi Yukihide, Koizumi Hideki
Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Ophthalmol Sci. 2022 Feb 8;2(2):100124. doi: 10.1016/j.xops.2022.100124. eCollection 2022 Jun.
To evaluate and compare the scleral thickness of patients with idiopathic central serous chorioretinopathy (iCSC) and steroid-induced central serous chorioretinopathy (sCSC) using anterior-segment OCT.
Retrospective, comparative study.
One hundred ten eyes of 110 patients with central serous chorioretinopathy.
We classified the patients into iCSC and sCSC groups and compared age, sex, spherical equivalent, axial length, subfoveal choroidal thickness (SCT), and scleral thickness. We measured scleral thickness 6 mm posterior to the scleral spur in 4 directions.
Scleral thickness in sCSC eyes.
We enrolled 96 and 14 eyes in the iCSC and sCSC groups, respectively. The sCSC group included a greater proportion of women than the iCSC group (42.9% and 13.5%, respectively; = 0.020). We observed no between-group differences in age, spherical equivalent, axial length, or SCT. Univariate analysis revealed that the sCSC group had a significantly thinner sclera at the superior (423.4 μm vs. 346.6 μm; < 0.001), temporal (440.1 μm vs. 399.4 μm; = 0.020), inferior (450.1 μm vs. 395.3 μm; = 0.001), and nasal (436.6 μm vs. 391.9 μm; = 0.002) points than the iCSC group. Multivariate analyses revealed that female sex (odds ratio, 4.322; 95% confidence interval, 1.025-18.224; = 0.046) and mean scleral thickness (odds ratio, 0.972; 95% confidence interval, 0.955-0.990; = 0.002) were significantly associated with sCSC.
The scleral thickness of eyes in the sCSC group was significantly thinner than that in the iCSC group. This suggests that the sclera has less involvement in the pathogenesis of sCSC than in that of iCSC.
使用眼前节光学相干断层扫描（OCT）评估和比较特发性中心性浆液性脉络膜视网膜病变（iCSC）和类固醇性中心性浆液性脉络膜视网膜病变（sCSC）患者的巩膜厚度。
回顾性比较研究。
110例中心性浆液性脉络膜视网膜病变患者的110只眼。
我们将患者分为iCSC组和sCSC组，比较年龄、性别、等效球镜度、眼轴长度、黄斑中心凹下脉络膜厚度（SCT）和巩膜厚度。我们在巩膜突后方6mm处的4个方向测量巩膜厚度。
sCSC组眼的巩膜厚度。
我们分别纳入iCSC组96只眼和sCSC组14只眼。sCSC组女性比例高于iCSC组（分别为42.9%和13.5%；P = 0.020）。我们观察到两组在年龄、等效球镜度、眼轴长度或SCT方面无差异。单因素分析显示，sCSC组在上（423.4μm对346.6μm；P < 0.001）、颞（440.1μm对399.4μm；P = 0.020）、下（450.1μm对395.3μm；P = 0.001）和鼻（436.6μm对391.9μm；P = 0.002）方位的巩膜明显比iCSC组薄。多因素分析显示，女性（比值比，4.322；95%置信区间，1.025 - 18.224；P = 0.046）和平均巩膜厚度（比值比，0.972；95%置信区间，0.955 - 0.990；P = 0.002）与sCSC显著相关。
sCSC组眼的巩膜厚度明显薄于iCSC组。这表明巩膜在sCSC发病机制中的参与程度低于iCSC。
