Chung Yoo-Ri, Kim Jong Wan, Kim Seung Woo, Lee Kihwang
Department of Ophthalmology, Ajou University School of Medicine, Suwon, Korea.
Retina. 2016 Sep;36(9):1652-7. doi: 10.1097/IAE.0000000000000998.
To investigate subfoveal choroidal thickness and subanalyze Haller and Sattler layers in eyes with central serous chorioretinopathy (CSC), uninvolved fellow eyes, and eyes of healthy controls using enhanced depth imaging optical coherence tomography.
Ocular findings and clinical features of 31 eyes with CSC, 24 fellow eyes and eyes of 30 healthy controls were analyzed retrospectively from October, 2014 to March, 2015. Subfoveal choroidal thickness was measured using enhanced depth imaging optical coherence tomography, and the thicknesses of Haller and Sattler layers were analyzed.
Mean subfoveal choroidal thickness and mean thickness of Haller layer were significantly greater in CSC than in fellow eyes (P = 0.043 and P = 0.036, respectively) and in normal control eyes (P < 0.001 each), and those of fellow eyes in CSC patients were significantly thicker than those in normal control eyes (P = 0.018 and P = 0.017, respectively). The thickness of Sattler layer did not differ significantly among these groups (P = 0.519).
Subfoveal choroidal thickness and the thickness of Haller layer were increased not only in affected but also in uninvolved fellow eyes of CSC patients. Nonvascular smooth muscle cells of the choroid may play a role in the pathophysiology of CSC, in response to increased sympathetic tone.
使用增强深度成像光学相干断层扫描技术，研究中心性浆液性脉络膜视网膜病变（CSC）患者患眼、对侧未受累眼以及健康对照者眼睛的黄斑下脉络膜厚度，并对哈勒层和萨特勒层进行亚分析。
回顾性分析2014年10月至2015年3月期间31例CSC患者的31只患眼、24只对侧眼以及30名健康对照者眼睛的眼部检查结果和临床特征。使用增强深度成像光学相干断层扫描技术测量黄斑下脉络膜厚度，并分析哈勒层和萨特勒层的厚度。
CSC患者患眼的平均黄斑下脉络膜厚度和哈勒层平均厚度显著大于对侧眼（分别为P = 0.043和P = 0.036）以及正常对照眼（均为P < 0.001），CSC患者对侧眼的上述指标显著厚于正常对照眼（分别为P = 0.018和P = 0.017）。这些组间萨特勒层厚度无显著差异（P = 0.519）。
CSC患者不仅患眼，而且对侧未受累眼的黄斑下脉络膜厚度和哈勒层厚度均增加。脉络膜的非血管平滑肌细胞可能在CSC的病理生理学中起作用，以应对交感神经张力增加。
