Suppr超能文献

心血管疾病干细胞治疗的机遇与挑战:2022年现状

Opportunities and challenges in stem cell therapy in cardiovascular diseases: Position standing in 2022.

作者信息

Mahmud Shabnur, Alam Safaet, Emon Nazim Uddin, Boby Umme Habiba, Ahmed Firoj, Monjur-Al-Hossain A S M, Tahamina Afroza, Rudra Sajib, Ajrin Marzina

机构信息

School of Health and Life Sciences, Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh.

Pharmaceutical Sciences Research Division, BCSIR Laboratories, Dhaka, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dr. Qudrat-I-Khuda Road, Dhanmondi, Dhaka 1205, Bangladesh.

出版信息

Saudi Pharm J. 2022 Sep;30(9):1360-1371. doi: 10.1016/j.jsps.2022.06.017. Epub 2022 Jun 22.

Abstract

This study intends to evaluate the development, importance, pre-clinical and clinical study evaluation of stem cell therapy for the treatment of cardiovascular disease. Cardiovascular disease is one of the main causes of fatality in the whole world. Though there are great progressions in the pharmacological and other interventional treatment options, heart diseases remain a common disorder that causes long-term warnings. Recent accession promotes the symptoms and slows down the adverse effects regarding cardiac remodelling. But they cannot locate the problems of immutable loss of cardiac tissues. In this case, stem cell treatment holds a promising challenge. Stem cells are the cells that are capable of differentiating into many cells according to their needs. So, it is assumed that these cells can distinguish into many cells and if these cells can be individualized into cardiac cells then they can be used to replace the damaged tissues of the heart. There is some abridgment in this therapy, none the less stem cell therapy remains a hopeful destination in the treatment of heart disease.

摘要

本研究旨在评估用于治疗心血管疾病的干细胞疗法的发展、重要性、临床前及临床研究评估。心血管疾病是全球主要死因之一。尽管在药物治疗和其他介入治疗方法方面取得了巨大进展,但心脏病仍然是一种常见疾病,会引发长期警报。近期的研究进展改善了症状并减缓了心脏重塑的不良影响。但它们无法解决心脏组织不可逆转损失的问题。在这种情况下,干细胞治疗面临着一项充满希望的挑战。干细胞是能够根据自身需求分化为多种细胞的细胞。因此,可以推测这些细胞能够分化为多种细胞,如果这些细胞能够分化为心脏细胞,那么它们就可用于替换受损的心脏组织。这种疗法存在一些不足,尽管如此,干细胞疗法在心脏病治疗中仍是一个充满希望的方向。

相似文献

1
Opportunities and challenges in stem cell therapy in cardiovascular diseases: Position standing in 2022.
Saudi Pharm J. 2022 Sep;30(9):1360-1371. doi: 10.1016/j.jsps.2022.06.017. Epub 2022 Jun 22.
2
Stem cells for cardiac repair: an introduction.
J Geriatr Cardiol. 2013 Jun;10(2):186-97. doi: 10.3969/j.issn.1671-5411.2013.02.003.
3
Mesenchymal stem cell therapy: A promising cell-based therapy for treatment of myocardial infarction.
J Gene Med. 2017 Dec;19(12). doi: 10.1002/jgm.2995. Epub 2017 Dec 8.
6
The Use of Mesenchymal Stem Cells and their Derived Extracellular Vesicles in Cardiovascular Disease Treatment.
Curr Stem Cell Res Ther. 2020;15(7):623-638. doi: 10.2174/1574888X15666200501235201.
7
Stem cells in cardiovascular disease: from cell biology to clinical therapy.
Intern Med J. 2002 May-Jun;32(5-6):259-65. doi: 10.1046/j.1445-5994.2002.00206.x.
8
Challenges to success in heart failure: Cardiac cell therapies in patients with heart diseases.
J Cardiol. 2016 Nov;68(5):361-367. doi: 10.1016/j.jjcc.2016.04.010. Epub 2016 Jun 21.
9
Cardiac stem cells and progenitors: developmental biology and therapeutic challenges.
Trans Am Clin Climatol Assoc. 2006;117:239-55; discussion 255-6.
10
Mesenchymal Stem Cells Therapies on Fibrotic Heart Diseases.
Int J Mol Sci. 2021 Jul 12;22(14):7447. doi: 10.3390/ijms22147447.

引用本文的文献

1
Cell Reprogramming, Transdifferentiation, and Dedifferentiation Approaches for Heart Repair.
Int J Mol Sci. 2025 Mar 27;26(7):3063. doi: 10.3390/ijms26073063.
2
The potential of ARL4C and its-mediated genes in atherosclerosis and agent development.
Front Pharmacol. 2025 Mar 19;16:1513340. doi: 10.3389/fphar.2025.1513340. eCollection 2025.
4
Revolutionizing medicine: recent developments and future prospects in stem-cell therapy.
Int J Surg. 2024 Dec 1;110(12):8002-8024. doi: 10.1097/JS9.0000000000002109.
5
To Repair a Broken Heart: Stem Cells in Ischemic Heart Disease.
Curr Issues Mol Biol. 2024 Mar 8;46(3):2181-2208. doi: 10.3390/cimb46030141.
6
Application and challenges of stem cells in cardiovascular aging.
Regen Ther. 2023 Nov 25;25:1-9. doi: 10.1016/j.reth.2023.11.009. eCollection 2024 Mar.

本文引用的文献

1
ac4C acetylation of RUNX2 catalyzed by NAT10 spurs osteogenesis of BMSCs and prevents ovariectomy-induced bone loss.
Mol Ther Nucleic Acids. 2021 Jul 2;26:135-147. doi: 10.1016/j.omtn.2021.06.022. eCollection 2021 Dec 3.
2
3
Advanced models of human skeletal muscle differentiation, development and disease: Three-dimensional cultures, organoids and beyond.
Curr Opin Cell Biol. 2021 Dec;73:92-104. doi: 10.1016/j.ceb.2021.06.004. Epub 2021 Aug 9.
4
Therapeutic Potential of Endothelial Progenitor Cells in Pulmonary Diseases.
Am J Respir Cell Mol Biol. 2021 Nov;65(5):473-488. doi: 10.1165/rcmb.2021-0152TR.
5
Embryonic stem cells go from bench to bedside for Parkinson's disease.
Cell Rep Med. 2021 Apr 20;2(4):100251. doi: 10.1016/j.xcrm.2021.100251.
7
Current situation and future of stem cells in cardiovascular medicine.
Biomed Pharmacother. 2020 Dec;132:110813. doi: 10.1016/j.biopha.2020.110813. Epub 2020 Oct 14.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验