Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Front Cell Infect Microbiol. 2022 Sep 28;12:1025889. doi: 10.3389/fcimb.2022.1025889. eCollection 2022.
To study the effect of precision probiotic strains transplantation capsules on diarrhea irritable bowel syndrome compared with fecal microbiota transplantation capsules and live combined bacillus subtilis and enterococcus faecium capsules.
Two patients with severe irritable bowel syndrome were treated with precision probiotic strains transplantation capsules, fecal microbiota transplantation capsules and live combined bacillus subtilis and enterococcus faecium capsules in sequence. IBS-SSS, IBS-QoL, GSRS, stool frequency, stool character, degree of abdominal pain, GAD-7, and PHQ9 scores of patients at 0, 2, 4, 6, 8, 10, and 12 weeks of treatment were monitored and recorded, and stool samples were collected for metagenomics and metabolomics.
It was found that the IBS-SSS score of patient case 1 decreased by 175 points and that of patient case 2 decreased by 100 points after treatment of precision probiotic strains transplantation capsules. There was no significant decrease after fecal microbiota transplantation capsules and live combined bacillus subtilis and enterococcus faecium capsules were used. At the same time, compared with fecal microbiota transplantation and live combined bacillus subtilis and enterococcus faecium capsules, the IBS QoL, stool frequency, stool character, degree of abdominal pain and GAD-7 score of patient case 1 improved more significantly by the precision probiotic strains transplantation capsules. And the stool frequency and stool character score of patient case 2 decreased more significantly. Intestinal microbiota also improved more significantly after the precise capsule transplantation treatment. And we found showed the same change trend in the treatment of two patients, which may play a role in the treatment.
precision probiotic strains transplantation capsules is more beneficial to improve the intestinal microbiota of patients than microbiota transplantation capsule and live combined bacillus subtilis and enterococcus faecium capsules, so as to better alleviate clinical symptoms. This study provides a more perfect and convenient therapeutic drugs for the treatment of IBS.
研究精准益生菌菌株移植胶囊对腹泻型肠易激综合征的影响，并与粪便微生物移植胶囊和枯草芽孢杆菌肠球菌双联活菌胶囊进行比较。
对 2 例严重肠易激综合征患者分别采用精准益生菌菌株移植胶囊、粪便微生物移植胶囊和枯草芽孢杆菌肠球菌双联活菌胶囊进行序贯治疗。分别于治疗前（0 周）及治疗后第 2、4、6、8、10、12 周，监测并记录患者 IBS-SSS、IBS-QoL、GSRS、大便频次、大便性状、腹痛程度、GAD-7、PHQ9 评分，同时收集粪便标本进行宏基因组学及代谢组学检测。
结果发现，患者 1 经精准益生菌菌株移植胶囊治疗后，IBS-SSS 评分下降 175 分，患者 2 下降 100 分；而使用粪便微生物移植胶囊和枯草芽孢杆菌肠球菌双联活菌胶囊后无明显下降。同时，与粪便微生物移植和枯草芽孢杆菌肠球菌双联活菌胶囊相比，精准益生菌菌株移植胶囊治疗后患者 1 的 IBS-QoL、大便频次、大便性状、腹痛程度及 GAD-7 评分改善更明显，且患者 2 的大便频次和大便性状评分下降更明显。经精准胶囊移植治疗后肠道菌群也得到了更明显的改善。且我们发现 在 2 例患者的治疗中均表现出相同的变化趋势，可能在治疗中发挥作用。
精准益生菌菌株移植胶囊较粪便微生物移植胶囊和枯草芽孢杆菌肠球菌双联活菌胶囊更有利于改善患者肠道菌群，从而更好地缓解临床症状。本研究为 IBS 的治疗提供了更完善、更便捷的治疗药物。
