KACC 91563 对小鼠脾细胞和巨噬细胞的免疫调节作用。
Immunomodulatory Effects by KACC 91563 in Mouse Splenocytes and Macrophages.
机构信息
Department of Food and Nutrition, Kyungnam University, Changwon 51767, Republic of Korea.
Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 05029, Republic of Korea.
出版信息
J Microbiol Biotechnol. 2019 Nov 28;29(11):1739-1744. doi: 10.4014/jmb.1812.12002.
The present study evaluates the immunomodulatory effect of KACC 91563 in murine primary splenocytes and macrophages. KACC 91563 regulated Tand B-cell proliferation and inhibited the Th1 (IL-2, IFN-γ)/Th2 (IL-4, IL-10) cytokine imbalance and immune cytokine production. Moreover, immunoglobulin E (IgE) levels were significantly lower after treatment with KACC 91563. These findings suggest that KACC 91563 could modulate the systemic immune system toward both IgE production and regulation of the Th1/Th2 balance.
本研究评估了 KACC 91563 在小鼠原代脾细胞和巨噬细胞中的免疫调节作用。KACC 91563 调节 T 细胞和 B 细胞增殖，抑制 Th1（IL-2、IFN-γ）/Th2（IL-4、IL-10）细胞因子失衡和免疫细胞因子产生。此外，用 KACC 91563 治疗后，免疫球蛋白 E（IgE）水平显著降低。这些发现表明，KACC 91563 可以调节全身性免疫系统，既能调节 IgE 的产生，又能调节 Th1/Th2 平衡。
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