Topić E, Zadro R, Granić M, Skrabalo Z
J Clin Chem Clin Biochem. 1987 Apr;25(4):261-4.
Blood sampling on filter paper was tested for determination of glycated haemoglobin. The method showed coefficients of variation of 3.4% and 4.1%, and linearity coefficients of 0.978 and 0.91 for the microchromatographic and colorimetric methods respectively. A blood sample on filter paper impregnated with 5% ethylene glycol solution remains stable for 8 days at room temperature. In a group of 30 diabetics educated in the filter paper blood sampling technique, no statistically significant differences were registered among the mean values of their blood glucose profiles, glycated haemoglobin levels determined at the hospital and those obtained at home 14 days after discharge. In conclusion, the use of blood spotted on filter paper seems a cheap and convenient method for collecting, storing and transporting samples for analysis of glycated haemoglobins. It is also a useful alternative for home monitoring of diabetics. Moreover, it could also be useful in epidemiological studies of diabetes.
对滤纸上的血样进行糖化血红蛋白测定测试。该方法显示，微色谱法和比色法的变异系数分别为3.4%和4.1%，线性系数分别为0.978和0.91。用5%乙二醇溶液浸渍的滤纸上的血样在室温下可稳定保存8天。在接受滤纸采血技术培训的30名糖尿病患者中，其血糖谱平均值、在医院测定的糖化血红蛋白水平与出院14天后在家中测得的糖化血红蛋白水平之间，未发现有统计学意义的差异。总之，使用滤纸上的血斑似乎是一种收集、储存和运输用于糖化血红蛋白分析样本的廉价且方便的方法。它也是糖尿病患者家庭监测的一种有用替代方法。此外，它在糖尿病流行病学研究中也可能有用。
