National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, Guangxi Medical University, Nanning, Guangxi, 530021, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health); Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China.
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health); Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China.
Colloids Surf B Biointerfaces. 2022 Dec;220:112894. doi: 10.1016/j.colsurfb.2022.112894. Epub 2022 Oct 3.
Doxorubicin (DOX) is a powerful chemotherapy drug for cancer treatment, especially in patients with advanced cancer. However, clinical use of DOX remains challenging due to its widespread drug resistance and severe cardiotoxicity. Here, we developed a novel DOX-loaded natural hydrogel microparticle by using microfluidic electrospray technology. The designed carboxymethyl cellulose-based hydrogel microparticles were cross-linked by iron ions and showed a sustained drug release. The animal experiments revealed that DOX-loaded microparticles had good biocompatibility when locally injected into tumor-bearing mice, and could enhance the effect of chemotherapy and effectively inhibit tumor growth without obvious toxicity. These features indicated that the natural biomass-based hydrogel microparticles are highly promising for chemotherapy drugs delivery and provide a platform for local therapy.
多柔比星（DOX）是一种用于癌症治疗的强效化疗药物，尤其适用于晚期癌症患者。然而，由于其广泛的耐药性和严重的心脏毒性，临床应用 DOX 仍然具有挑战性。在这里，我们使用微流控电喷雾技术开发了一种新型 DOX 负载的天然水凝胶微球。设计的基于羧甲基纤维素的水凝胶微球通过铁离子交联，具有持续的药物释放。动物实验表明，局部注射到荷瘤小鼠体内的载 DOX 微球具有良好的生物相容性，能够增强化疗效果，有效抑制肿瘤生长，且无明显毒性。这些特性表明，基于天然生物质的水凝胶微球非常有希望用于化疗药物递送，并为局部治疗提供了一个平台。
