State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning 530021, China.
Int J Mol Sci. 2024 Jun 14;25(12):6556. doi: 10.3390/ijms25126556.
Cancer is a significant global public health issue with increasing morbidity and mortality rates. To address this challenge, novel drug carriers such as nano-materials, liposomes, hydrogels, fibers, and microspheres have been extensively researched and utilized in oncology. Among them, polymer microspheres are gaining popularity due to their ease of preparation, excellent performance, biocompatibility, and drug-release capabilities. This paper categorizes commonly used materials for polymer microsphere preparation, summarizes various preparation methods (emulsification, phase separation, spray drying, electrospray, microfluidics, and membrane emulsification), and reviews the applications of polymer microspheres in cancer diagnosis, therapy, and postoperative care. The current status and future development directions of polymer microspheres in cancer treatment are analyzed, highlighting their importance and potential for improving patient outcomes.
癌症是一个重大的全球公共卫生问题，发病率和死亡率不断上升。为了应对这一挑战，新型药物载体，如纳米材料、脂质体、水凝胶、纤维和微球，已在肿瘤学领域得到广泛研究和应用。其中，聚合物微球因其制备简便、性能优良、生物相容性和药物释放能力而受到关注。本文对聚合物微球制备常用材料进行分类，总结各种制备方法（乳化、相分离、喷雾干燥、电喷雾、微流控和膜乳化），综述聚合物微球在癌症诊断、治疗和术后护理中的应用。分析了聚合物微球在癌症治疗中的现状和未来发展方向，强调了其提高患者治疗效果的重要性和潜力。
