Research Department of Primary Care and Population Health, University College London, London.
UCL School of Pharmacy, University College London, London.
Br J Gen Pract. 2022 Dec 21;73(726):e9-e15. doi: 10.3399/BJGP.2022.0111. Print 2023 Jan.
Postural hypotension is a common condition associated with adverse outcomes in older adults. General practice plays an important role in identification of the condition.
To examine the incidence of postural hypotension between 2008 and 2018 in general practice and how trends vary by age, sex, year, and social deprivation.
Retrospective cohort study using electronic health records from the IQVIA Medical Research Data (IMRD) between 2008 and 2018.
Patients were included if they were aged ≥50 years. Incident postural hypotension was identified as a new (first) recording of a postural hypotension code. Recording of incident postural hypotension was estimated per 10 000 person-years at risk (PYAR) according to age, sex, year, and social deprivation. Incident rate ratios were estimated by multivariable Poisson regression.
Of 2 911 260 patients, 24 973 had an electronic record indicating a new diagnosis of postural hypotension between 2008 and 2018. This was equivalent to 17.9 cases per 10 000 PYAR in males (95% confidence interval [CI] = 17.6 to 18.2) and 16.2 cases per 10 000 PYAR in females (95% CI = 15.9 to 16.5). A significant age-sex interaction was identified. Recorded postural hypotension rate increased with age and social deprivation, and reduced between 2008 and 2018. The rate was higher in males compared with females, particularly in older age groups (>80 years).
To the authors' knowledge, this is the first study to quantify incident recorded postural hypotension in general practice. The rate is lower than expected compared with studies in screened older populations. Potential barriers to identification include underreporting, underdetection owing to lack of time and/or poorly standardised methods of measurement, and poor coding. Future research should investigate current practice and approaches for increased detection such as education, practical methods of screening, and standardised measurement of postural blood pressure.
体位性低血压是与老年人不良结局相关的常见病症。全科医疗在识别该病症方面发挥着重要作用。
调查 2008 年至 2018 年期间全科医疗中体位性低血压的发病率,以及年龄、性别、年份和社会剥夺程度对其趋势的影响。
使用 2008 年至 2018 年 IQVIA 医疗研究数据(IMRD)中的电子健康记录进行回顾性队列研究。
纳入年龄≥50 岁的患者。体位性低血压的新发病例定义为首次出现体位性低血压编码的记录。根据年龄、性别、年份和社会剥夺程度,计算每 10000 人年风险(PYAR)中的新发体位性低血压病例数。通过多变量泊松回归估计发病率比。
在 2911260 名患者中,2008 年至 2018 年期间有 24973 名患者的电子记录显示新发体位性低血压诊断。这相当于男性每 10000PYAR 中 17.9 例(95%置信区间 [CI] = 17.6 至 18.2),女性每 10000PYAR 中 16.2 例(95% CI = 15.9 至 16.5)。发现年龄-性别存在显著交互作用。记录的体位性低血压发生率随年龄和社会剥夺程度的增加而增加,并在 2008 年至 2018 年期间降低。与女性相比,男性的发生率更高,尤其是在年龄较大的组(>80 岁)。
据作者所知,这是第一项在全科医疗中量化记录的新发体位性低血压的研究。与在筛查的老年人群中进行的研究相比,该发病率较低。可能存在识别障碍,包括报告不足、由于缺乏时间和/或测量方法不规范以及编码不良而导致的漏诊。未来的研究应调查当前的实践和增加检测的方法,如教育、筛选的实用方法和体位血压的标准化测量。