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巴西乙型肝炎的地区差异和时间趋势分析。

Regional differences and temporal trend analysis of Hepatitis B in Brazil.

机构信息

Infectious Diseases Division, Escola Paulista de Medicina, Hospital São Paulo, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Institute of Mathematics and Statistics, The University of São Paulo, São Paulo, SP, Brazil.

出版信息

BMC Public Health. 2022 Oct 17;22(1):1931. doi: 10.1186/s12889-022-14296-1.

DOI:10.1186/s12889-022-14296-1
PMID:36253757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9578265/
Abstract

BACKGROUND

Burden disease related to chronic HBV infection is increasing worldwide. Monitoring Hepatitis B occurrence is difficult due to intrinsic characteristics of the infection, nonetheless analyzing this information improves strategic planning towards reducing the burden related to chronic infection. In this line of thought, this study aims to analyze national and regional epidemiology of Hepatitis B and it's temporal trends based on Brazilian reported cases.

METHODS

Data obtained from the Brazilian National Notifiable Disease Reporting System (SINAN) from 2007 to 2018 were classified by infection status with an original classification algorithm, had their temporal trends analyzed by Joinpoint regression model and were correlated with gender, age and region.

RESULTS

Of the 487,180 hepatitis B cases notified to SINAN, 97.65% had it infection status correctly classified by the new algorithm. Hepatitis B detection rate, gender and age-distribution were different among Brazilian regions. Overall, detection rates remained stable from 2007 to 2018, achieving their maximal value (56.1 cases per 100,000 inhabitants) in North region. However, there were different temporal trends related to different hepatitis B status and age. Women mean age at notification were always inferior to those of men and the difference was higher in Central-West, North and Northeast regions.

CONCLUSION

Hepatitis B affects heterogeneously different populations throughout Brazilian territory. The differences shown in its temporal trends, regional, gender and age-related distribution helps the planning and evaluation of control measures in Brazil.

摘要

背景

全球范围内与慢性乙型肝炎病毒感染相关的疾病负担不断增加。由于感染的固有特征，监测乙型肝炎的发生较为困难，但分析这些信息可改善减少慢性感染相关负担的战略规划。基于此，本研究旨在分析基于巴西报告病例的乙型肝炎的国家和地区流行病学及其时间趋势。

方法

本研究从 2007 年至 2018 年从巴西国家法定传染病报告系统（SINAN）中获取数据，按照感染状态对数据进行分类，使用原始分类算法，并通过 Joinpoint 回归模型分析其时间趋势，并与性别、年龄和地区相关联。

结果

在向 SINAN 报告的 487,180 例乙型肝炎病例中，97.65%的病例感染状态通过新算法正确分类。巴西各地区的乙型肝炎检出率、性别和年龄分布均不同。总体而言，2007 年至 2018 年期间，乙型肝炎的检出率保持稳定，在北部地区达到最高值（每 10 万人中有 56.1 例）。然而，不同的乙型肝炎状态和年龄与不同的时间趋势相关。通知时女性的平均年龄始终低于男性，在中西部、北部和东北部地区差异更大。

结论

乙型肝炎在巴西各地不同人群中的影响存在差异。其时间趋势、地区、性别和年龄分布的差异有助于巴西控制措施的规划和评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0799/9578265/f9f139f206a0/12889_2022_14296_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0799/9578265/9b3df07239fd/12889_2022_14296_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0799/9578265/cdcb92d5846c/12889_2022_14296_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0799/9578265/3d17990f6cc2/12889_2022_14296_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0799/9578265/f9f139f206a0/12889_2022_14296_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0799/9578265/9b3df07239fd/12889_2022_14296_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0799/9578265/cdcb92d5846c/12889_2022_14296_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0799/9578265/3d17990f6cc2/12889_2022_14296_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0799/9578265/f9f139f206a0/12889_2022_14296_Fig4_HTML.jpg

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