Lampe Elisabeth, Mello Francisco C A, do Espírito-Santo Marcia P, Oliveira Cintia M C, Bertolini Dennis A, Gonçales Neiva S L, Moreira Regina C, Fernandes Carlos A S, Nascimento Haydée C L, Grotto Rejane M T, Pardini Maria Inês M C
Laboratório de Hepatites Virais, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil.
Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, Brazil.
J Gen Virol. 2017 Jun;98(6):1389-1398. doi: 10.1099/jgv.0.000789. Epub 2017 Jun 20.
The influence of hepatitis B virus (HBV) genotypes in the natural history of the disease and its response to antiviral treatment have been addressed in many studies. In Brazil, studies on HBV genotype circulation have been restricted to specific population groups and states. Here, we have conducted a nationwide multicentre study with an unprecedented sample size representing all Brazilian regions in an effort to better understand the viral variants of HBV circulating among chronic carriers. Seven HBV genotypes were found circulating in Brazil. Overall, HBV/A was the most prevalent, identified in 589 (58.7 %) samples, followed by HBV/D (23.4 %) and HBV/F (11.3 %). Genotypes E, G, C and B were found in a minor proportion. The distribution of the genotypes differed markedly from the north to the south of the country. While HBV/A was the most prevalent in the North (71.6 %) and Northeast (65.0 %) regions, HBV/D was found in 78.9 % of the specimens analysed in the South region. HBV/F was the second most prevalent genotype in the Northeast region (23.5 %). It was detected in low proportions (7 to 10 %) in the North, Central-West and Southeast regions, and in only one sample in the South region. HBV/E was detected in all regions except in the South, while monoinfection with HBV/G was found countrywide, with the exception of Central-West states. Our sampling covered 24 of the 26 Brazilian states and the Federal District and is the first report of genotype distribution in seven states. This nationwide study provides the most complete overview of HBV genotype distribution in Brazil to date and reflects the origin and plurality of the Brazilian population.
许多研究探讨了乙型肝炎病毒（HBV）基因型对疾病自然史及其抗病毒治疗反应的影响。在巴西，关于HBV基因型传播的研究仅限于特定人群和州。在此，我们开展了一项全国性多中心研究，样本量空前，涵盖巴西所有地区，旨在更好地了解慢性携带者中传播的HBV病毒变体。在巴西发现有7种HBV基因型在传播。总体而言，HBV/A最为普遍，在589份（58.7%）样本中被鉴定出来，其次是HBV/D（23.4%）和HBV/F（11.3%）。E、G、C和B基因型的比例较小。基因型的分布在该国北部和南部明显不同。虽然HBV/A在北部（71.6%）和东北部（65.0%）地区最为普遍，但在南部地区分析的78.9%的标本中发现了HBV/D。HBV/F是东北部地区第二普遍的基因型（23.5%）。在北部、中西部和东南部地区检测到的比例较低（7%至10%），在南部地区仅在一个样本中检测到。除南部外，在所有地区均检测到HBV/E，而除中西部各州外，在全国范围内均发现了HBV/G单一感染。我们的采样覆盖了巴西26个州中的24个州以及联邦区，这是7个州基因型分布的首次报告。这项全国性研究提供了迄今为止巴西HBV基因型分布最完整的概述，反映了巴西人口的起源和多样性。
