Tosi P, Luzi P, Baak J P, Miracco C, Vindigni C, Lio R, Barbini P
J Pathol. 1987 Jun;152(2):83-94. doi: 10.1002/path.1711520204.
The grading systems of gastric dysplasia suffer from the lack of criteria that separate the changes with an acceptable reproducibility. Repeatable and objective grading of the lesion can be obtained by morphometrically measuring histological criteria normally employed in qualitative grading. In 54 consecutive antrum biopsy specimens in which a blind, independent agreement on the grade of dysplasia had been reached between four independent pathologists, stereological and nuclear morphometrical features have been studied. Single variate, bivariate and multivariate analyses have been performed. Architectural parameters, such as volume and surface densities of glands and epithelium, are especially good discriminators both between mild and moderate, and between moderate and severe dysplasia. Features describing arrangement and shape of nuclei, and nucleolar size are of additional help in improving the objective distinction between moderate and severe dysplasia.
胃发育异常的分级系统缺乏具有可接受重复性的区分改变的标准。通过形态计量学测量定性分级中通常使用的组织学标准，可以获得病变的可重复且客观的分级。在54例连续的胃窦活检标本中，四位独立病理学家对发育异常的分级达成了盲法、独立的一致意见，在此基础上对立体学和核形态计量学特征进行了研究。进行了单变量、双变量和多变量分析。结构参数，如腺体和上皮的体积和表面密度，在区分轻度与中度以及中度与重度发育异常方面都是特别好的判别指标。描述细胞核排列和形状以及核仁大小的特征在改善中度与重度发育异常的客观区分方面有额外帮助。
