Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, 110001 Liaoning, China.
Comput Math Methods Med. 2022 Oct 8;2022:1956908. doi: 10.1155/2022/1956908. eCollection 2022.
Despite guidelines provided by the Brain Trauma Foundation (BTF) for treating patients with TBI, including advice to monitor intracranial pressure (ICP), the clinical application of ICP monitoring is far from universal. This laxity has been attributed to the relationship between mortality in TBI patients and ICP monitoring.
This systematic review and meta-analysis was aimed at determining the effect of intracranial pressure (ICP) monitoring on the mortality of patients with traumatic brain injury (TBI).
A systematic search for articles was conducted on PubMed, Scopus, Cochrane Central Register of Control Trials (CENTRAL), and APA PsycNet for articles published from 1 January 2000 to 1 August 2022. Manager 5.4 was used to carry out statistical analysis.
Article search yielded 1421 articles, but only 23 cohort studies were included in the systematic review and meta-analysis. The total number of study participants is 80,058. Seventeen studies reported unadjusted odds ratios (OR), and only 8 reported the adjusted odds ratio (OR). Nine out of seventeen studies reported an unadjusted OR of less than 1, and five out of eight studies reported an adjusted OR of less than 1. From this paper's analysis, the OR for in-hospital mortality was 1.01 [95% CI, 0.80, 1.28], with a value of 0.92. OR for ICU mortality was 0.84 [95% CI, 0.52, 1.35], with a value of 0.47.
But due to conflicting results, as evident above, it is unsatisfyingly challenging to draw any substantial conclusions from them. This paper thus calls for more research on this particular paper.
尽管颅脑外伤基金会（BTF）为 TBI 患者提供了包括监测颅内压（ICP）在内的治疗指南，但 ICP 监测的临床应用远未普及。这种宽松被归因于 TBI 患者死亡率与 ICP 监测之间的关系。
本系统评价和荟萃分析旨在确定颅内压（ICP）监测对创伤性脑损伤（TBI）患者死亡率的影响。
对 PubMed、Scopus、Cochrane 中央对照试验注册中心（CENTRAL）和 APA PsycNet 自 2000 年 1 月 1 日至 2022 年 8 月 1 日发表的文章进行系统搜索。使用 Manager 5.4 进行统计分析。
文章搜索共产生了 1421 篇文章，但只有 23 项队列研究被纳入系统评价和荟萃分析。研究参与者总数为 80058 人。17 项研究报告了未经调整的优势比（OR），只有 8 项研究报告了调整后的优势比（OR）。17 项研究中有 9 项报告了未经调整的 OR 小于 1，8 项研究中有 5 项报告了调整后的 OR 小于 1。从本文的分析中，住院死亡率的 OR 为 1.01[95%CI，0.80，1.28]，值为 0.92。ICU 死亡率的 OR 为 0.84[95%CI，0.52，1.35]，值为 0.47。
但由于上述结果存在冲突，因此很难从中得出实质性结论。因此，本文呼吁对这一特定论文进行更多的研究。
