Takada M, Watanabe J
J Pharmacobiodyn. 1987 Mar;10(3):124-7. doi: 10.1248/bpb1978.10.124.
The redox level of [14C]coenzyme Q10 solubilized with HCO-60 in the livers of guinea pigs at 24 h after intravenous injection was approximately 1/4 (18.2% vs. 63.4%) of that of [14C]coenzyme Q10 solubilized with ethanol-water (1:5 by vol). Further, the redox level of coenzyme Q10 (Q10) solubilized with HCO-60 or ethanol-water was 20.2 or 82.3%, respectively, after a 30-min incubation in the liver cytosol. Q10 solubilized with HCO-60 was thus reduced only slightly in vivo or in vitro. The critical micelle concentrations of HCO-60 in the absence and presence of Q10 were 0.02 and 0.002% (w/v), respectively. The concentrations of HCO-60 micelles containing Q10 were estimated to be 0.0048% (w/v) in the incubation mixture with cytosol and 0.0041% (w/v) in blood circulation. These results suggest that HCO-60 micelles containing Q10 would remain more stable not only in blood circulation but also in tissues as compared with ethanol-water emulsion. A possible mode of solubilization of Q10 is discussed.
静脉注射后24小时，豚鼠肝脏中用HCO - 60增溶的[¹⁴C]辅酶Q10的氧化还原水平约为用乙醇 - 水（体积比1:5）增溶的[¹⁴C]辅酶Q10的1/4（18.2%对63.4%）。此外，在肝细胞溶胶中孵育30分钟后，用HCO - 60或乙醇 - 水增溶的辅酶Q10（Q10）的氧化还原水平分别为20.2%或82.3%。因此，用HCO - 60增溶的Q10在体内或体外仅轻微还原。在不存在和存在Q10的情况下，HCO - 60的临界胶束浓度分别为0.02%和0.002%（w/v）。在与细胞溶胶的孵育混合物中，含Q10的HCO - 60胶束浓度估计为0.0048%（w/v），在血液循环中为0.0041%（w/v）。这些结果表明，与乙醇 - 水乳剂相比，含Q10的HCO - 60胶束不仅在血液循环中而且在组织中会保持更稳定。讨论了Q10可能的增溶模式。
