美国肝脏脂肪定量背散射：AIUM-RSNA QIBA 脉冲回波定量超声倡议。
US Backscatter for Liver Fat Quantification: An AIUM-RSNA QIBA Pulse-Echo Quantitative Ultrasound Initiative.
机构信息
From the Center for Devices and Radiological Health, U.S. Food and Drug Administration, 10903 New Hampshire Ave, WO62, Room 2114, Silver Spring, MD 20993 (K.A.W.); Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Ill (A.H.); Department of Radiology, University of Michigan, Ann Arbor, Mich (J.M.R.); Ultrasound Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Engineering, Pontificia Universidad Católica del Perú, Lima, Peru (R.L.); Laboratory of Biorheology and Medical Ultrasonics, University of Montreal Hospital Research Center, Montreal, Canada (G.C.); Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Division of Radiotherapy and Imaging, Joint Department of Physics, London, UK (J.B.); and Pfizer, Cambridge, Mass (T.T.).
出版信息
Radiology. 2022 Dec;305(3):526-537. doi: 10.1148/radiol.220606. Epub 2022 Oct 18.
Nonalcoholic fatty liver disease (NAFLD) is believed to affect one-third of American adults. Noninvasive methods that enable detection and monitoring of NAFLD have the potential for great public health benefits. Because of its low cost, portability, and noninvasiveness, US is an attractive alternative to both biopsy and MRI in the assessment of liver steatosis. NAFLD is qualitatively associated with enhanced B-mode US echogenicity, but visual measures of B-mode echogenicity are negatively affected by interobserver variability. Alternatively, quantitative backscatter parameters, including the hepatorenal index and backscatter coefficient, are being investigated with the goal of improving US-based characterization of NAFLD. The American Institute of Ultrasound in Medicine and Radiological Society of North America Quantitative Imaging Biomarkers Alliance are working to standardize US acquisition protocols and data analysis methods to improve the diagnostic performance of the backscatter coefficient in liver fat assessment. This review article explains the science and clinical evidence underlying backscatter for liver fat assessment. Recommendations for data collection are discussed, with the aim of minimizing potential confounding effects associated with technical and biologic variables.
非酒精性脂肪性肝病（NAFLD）被认为影响了三分之一的美国成年人。能够检测和监测 NAFLD 的非侵入性方法具有巨大的公共卫生效益。由于其成本低、便携性和非侵入性，US 在评估肝脂肪变性方面，是活检和 MRI 的有吸引力的替代方法。NAFLD 与增强的 B 模式 US 回声强度定性相关，但 B 模式回声强度的视觉测量受到观察者间变异性的负面影响。相反，包括肝肾指数和背散射系数在内的定量背散射参数正在被研究，以提高基于 US 的 NAFLD 特征描述。美国超声医学研究所和北美放射学会定量成像生物标志物联盟正在努力标准化 US 采集协议和数据分析方法，以提高背散射系数在肝脂肪评估中的诊断性能。本文综述了用于肝脂肪评估的背散射的科学和临床证据。讨论了数据采集的建议，目的是最小化与技术和生物学变量相关的潜在混杂影响。
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