State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.
Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.
Analyst. 2022 Nov 7;147(22):4962-4970. doi: 10.1039/d2an01317g.
High-throughput automated manipulation of microparticles in complex-shaped environments has been demonstrated with great potential in the field of pharmaceutical microfluidics. Generally, the development of a highly efficient actuation method for functional microparticle manipulation in complex-shaped chamber structures is the key challenge of this technology. Here, we present a novel traveling surface acoustic wave (TSAW)-based manipulation device that allows for automated and high-throughput maze-solving manipulation of microparticles inside complex round-shaped and square-shaped maze chambers. This technology relies on the localized acoustic streaming effects generated by TSAWs, which are capable of automatically trapping microparticles and driving them to move along the determined trajectories based on the topographic features of the maze chamber. Numerical modelling and simulation were conducted to demonstrate the feasibility of our proposed device for targeted microparticle transportation in complex-shaped maze chamber environments. In addition, by configuring the excitation of electric signals of interdigital transducers (IDTs), such as excitation frequency and input voltage, the motion velocity of microparticles can be rapidly adjusted within 0.1 s. Thus, our device enables low-cost, compact, and contactless trajectory manipulation of high-throughput microparticles inside chambers with complex topographical features and would have application in cell-directed transportation, low-volume chemical mixing, and precise drug delivery.
在药物微流控领域，已经证明了在复杂形状环境中进行高通量自动化微粒子操作具有巨大的潜力。通常，开发一种在复杂形状腔结构中用于功能微粒子操作的高效致动方法是这项技术的关键挑战。在这里，我们提出了一种新颖的基于行波声表面波（TSAW）的操纵装置，允许在复杂的圆形和方形迷宫腔室内对微粒子进行自动化和高通量的迷宫求解操作。这项技术依赖于 TSAWs 产生的局部声流效应，能够根据迷宫腔的地形特征自动捕获微粒子并驱动它们沿着确定的轨迹移动。通过数值建模和模拟，证明了我们提出的用于在复杂形状迷宫腔环境中靶向微粒子运输的设备的可行性。此外，通过配置叉指换能器（IDT）的电信号激励，例如激励频率和输入电压，可以在 0.1s 内快速调整微粒子的运动速度。因此，我们的设备可以在具有复杂地形特征的腔室内低成本、紧凑且非接触式地对高通量微粒子进行轨迹操纵，可应用于细胞定向运输、小体积化学混合和精确药物输送。
