来自辣木籽的具有神经保护活性的吡咯-2-甲醛。
Pyrrole-2-carbaldehydes with neuroprotective activities from Moringa oleifera seeds.
作者信息
Jiang Yueping, Liu Rong, Li Jing, Huang Qi, Liu Shao, He Jia
机构信息
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China; Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China; Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
出版信息
Phytochemistry. 2022 Dec;204:113451. doi: 10.1016/j.phytochem.2022.113451. Epub 2022 Oct 17.
Seven undescribed pyrrole-2-carbaldehydes (pyrrolemorines A-G), along with four known analogs, were isolated from the aqueous extract of Moringa oleifera seeds. The structures were elucidated by comprehensive spectroscopic and chemical analyses using HRMS and NMR spectra, acid hydrolysis, and Rh(OCOCF)-induced ECD experiments. Pyrrolemorines A, E, and pyrrolemarumine displayed neuroprotective activities against oxygen-glucose deprivation/reperfusion injury in PC12 cells by regulating NF-κb and Nrf2.
从辣木籽水提取物中分离出7种未描述的吡咯-2-甲醛（吡咯莫林A-G）以及4种已知类似物。通过使用高分辨质谱（HRMS）和核磁共振（NMR）光谱、酸水解以及铑（OCOCF）诱导的电子圆二色（ECD）实验进行综合光谱和化学分析来阐明其结构。吡咯莫林A、E和吡咯拉鲁明通过调节核因子κB（NF-κb）和核因子E2相关因子2（Nrf2）对PC12细胞中的氧糖剥夺/再灌注损伤表现出神经保护活性。
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