Impact of pre-existing subclinical depressive symptoms on the mental health of older adults during the COVID-19-related confinements: assessment of moderating factors including meditation training.

The COVID-19 pandemic significantly challenged mental health of populations worldwide. We aimed to assess changes in mental health of cognitively unimpaired (CU) older adults with pre-existing subclinical depressive symptoms during pandemic-related confinements, and the factors that could modulate these changes. CU older adults with (DepS, n = 53) and without (NoDepS, n = 47) pre-existing subclinical depressive symptoms (defined using the Geriatric Depression Scale at baseline) from the Age-Well randomized controlled trial (NCT02977819) were included - for whom data at baseline, post-intervention visits and during the two national confinements were available. The 18-month meditation or non-native language training intervention was completed before the pandemic. DepS, compared to NoDepS, had higher levels of depressive and anxiety symptoms at all assessments, including confinements. DepS had a greater increase in anxiety than NoDepS between the two confinements, and this increase was associated with greater ruminative brooding at baseline, but was not moderated by the meditation training intervention or by meditation practice during confinements. Pre-existing subclinical depressive symptoms in older adults contribute to mental health deterioration during confinements, with rumination being the main factor involved - stressing the need to treat these symptoms.