酒精使用障碍患者的执行功能障碍:一项系统评价

Executive Dysfunction in Patients With Alcohol Use Disorder: A Systematic Review.

作者信息

Maharjan Shrinkhala, Amjad Zainab, Abaza Abdelrahman, Vasavada Advait M, Sadhu Akhil, Valencia Carla, Fatima Hameeda, Nwankwo Ijeoma, Anam Mahvish, Mohammed Lubna

机构信息

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Internal Medicine, College of Medicine, King Faisal University, Al Ahsa, SAU.

出版信息

Cureus. 2022 Sep 15;14(9):e29207. doi: 10.7759/cureus.29207. eCollection 2022 Sep.

Abstract

A medical condition known as alcohol use disorder (AUD) is defined as an impaired capacity to reduce or regulate alcohol consumption despite negative social, occupational, or health effects. According to studies, habitual drinkers experience a reduction in their capacity to process new information, gain new skills, and formulate plans. Studies indexed in PubMed, PubMed Central, Google Scholar, ResearchGate, and ScienceDirect, published from 2012 to 2022, were identified through the search terms "alcohol use disorder" and "executive function." A total of 2242 abstracts were identified through the initial search terms. Full texts were reviewed for 61 articles, out of which nine articles met the criteria for inclusion. This systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The current systematic review primarily focuses on the following issues: clinical neuropsychological tests of executive dysfunction, specific brain regions most affected by alcohol neurotoxic effects, and alcohol-related dementia. This review concluded that chronic alcohol dependence syndrome causes impairments in several cognitive function domains. Study shows frontal lobe damage is caused by chronic alcohol consumption. A faulty interaction among large-scale networks underlies patients' executive dysfunction in AUD, which is suggested by changes in prefrontal white-matter pathways. The goal of this systematic review is to improve the ability to recognize alcoholics who are particularly at risk of functional impairments to tailor therapeutic therapy to maximize the chance of maintaining abstinence and neuropsychology concerning this complex disease.

摘要

一种被称为酒精使用障碍(AUD)的医学状况被定义为尽管存在负面的社会、职业或健康影响,但减少或调节酒精消费的能力受损。根据研究,习惯性饮酒者处理新信息、获取新技能和制定计划的能力会下降。通过搜索词“酒精使用障碍”和“执行功能”,确定了2012年至2022年在PubMed、PubMed Central、谷歌学术、ResearchGate和ScienceDirect上索引的研究。通过初始搜索词共确定了2242篇摘要。对61篇文章的全文进行了审查,其中9篇文章符合纳入标准。本系统评价基于系统评价和Meta分析的首选报告项目(PRISMA)指南。当前的系统评价主要关注以下问题:执行功能障碍的临床神经心理学测试、受酒精神经毒性影响最严重的特定脑区以及与酒精相关的痴呆。该评价得出结论,慢性酒精依赖综合征会导致几个认知功能领域的损害。研究表明,慢性饮酒会导致额叶损伤。前额叶白质通路的变化表明,大规模网络之间的错误相互作用是AUD患者执行功能障碍的基础。本系统评价的目的是提高识别特别有功能障碍风险的酗酒者的能力,以便量身定制治疗方案,最大限度地提高保持戒酒的机会,并改善关于这种复杂疾病的神经心理学。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a83/9573267/c185cf6bdbff/cureus-0014-00000029207-i01.jpg

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