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异基因造血干细胞移植受者播散性弓形虫病：一例报告及当前文献综述

Disseminated Toxoplasmosis in an Allogeneic Hematopoietic Stem Cell Transplant Recipient: A Case Report and Review of the Current Literature.

作者信息

Baluch Aliyah, Handley Guy, Ludlow Steven, Morrison Austin, Velez Ana, Rojas Marcia C, Pasikhova Yanina

机构信息

Infectious Diseases, Moffitt Cancer Center, Tampa, USA.

Infectious Diseases, University of South Florida Morsani College of Medicine, Tampa, USA.

出版信息

Cureus. 2022 Sep 15;14(9):e29185. doi: 10.7759/cureus.29185. eCollection 2022 Sep.

DOI:10.7759/cureus.29185
PMID:36259018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9569131/
Abstract

Reactivation infections in hematopoietic stem cell transplants are mitigated by prophylactic regimens. Despite high rates of exposure, morbidity and mortality secondary to toxoplasmosis are limited to subsets of patients such as immunocompromised persons. We describe the first case of disseminated toxoplasmosis in a double umbilical cord blood transplant recipient.

摘要

预防性治疗方案可减轻造血干细胞移植中的再激活感染。尽管暴露率很高，但弓形虫病继发的发病率和死亡率仅限于免疫功能低下者等患者亚群。我们描述了首例双份脐带血移植受者发生播散性弓形虫病的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbdf/9569131/423081e5b7d2/cureus-0014-00000029185-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbdf/9569131/3120221adf36/cureus-0014-00000029185-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbdf/9569131/423081e5b7d2/cureus-0014-00000029185-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbdf/9569131/3120221adf36/cureus-0014-00000029185-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbdf/9569131/423081e5b7d2/cureus-0014-00000029185-i02.jpg

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1
Disseminated Toxoplasmosis in an Allogeneic Hematopoietic Stem Cell Transplant Recipient: A Case Report and Review of the Current Literature.异基因造血干细胞移植受者播散性弓形虫病：一例报告及当前文献综述
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本文引用的文献

1
Parasitic Infections in Hematopoietic Stem Cell Transplantation.造血干细胞移植中的寄生虫感染
Mediterr J Hematol Infect Dis. 2016 Jul 1;8(1):e2016035. doi: 10.4084/MJHID.2016.035. eCollection 2016.
2
Toxoplasmosis in cord blood transplantation recipients.
Transpl Infect Dis. 2012 Oct;14(5):496-501. doi: 10.1111/j.1399-3062.2012.00735.x. Epub 2012 May 1.
3
Multisystem febrile illness in a cord-blood transplant recipient.
Clin Infect Dis. 2010 Sep 15;51(6):716-7, 749-50. doi: 10.1086/655896.
4
Guidelines for preventing infectious complications among hematopoietic cell transplant recipients: a global perspective. Preface.造血细胞移植受者感染并发症预防指南：全球视角。前言。
Bone Marrow Transplant. 2009 Oct;44(8):453-5. doi: 10.1038/bmt.2009.254.
5
Prevention of toxoplasmosis in transplant patients.移植患者弓形虫病的预防
Clin Microbiol Infect. 2008 Dec;14(12):1089-101. doi: 10.1111/j.1469-0691.2008.02091.x.
6
Disseminated toxoplasmosis resulting in graft failure in a cord blood stem cell transplant recipient.
Pediatr Blood Cancer. 2007 Feb;48(2):222-6. doi: 10.1002/pbc.20537.
7
Toxoplasmosis in bone marrow transplantation: a report of two cases and systematic review of the literature.骨髓移植中的弓形虫病：两例报告及文献系统综述
Bone Marrow Transplant. 2002 Apr;29(8):691-8. doi: 10.1038/sj.bmt.1703425.
8
Toxoplasmosis, a severe complication in allogeneic hematopoietic stem cell transplantation: successful treatment strategies during a 5-year single-center experience.弓形虫病，异基因造血干细胞移植中的一种严重并发症：一项单中心5年经验中的成功治疗策略
Clin Infect Dis. 2001 Jan;32(1):E1-8. doi: 10.1086/317548. Epub 2000 Dec 11.
9
Diagnosis of toxoplasmosis in bone marrow transplant recipients: comparison of PCR-based results and immunohistochemistry.骨髓移植受者弓形虫病的诊断：基于聚合酶链反应（PCR）的结果与免疫组织化学的比较
Bone Marrow Transplant. 2000 Jun;25(12):1257-62. doi: 10.1038/sj.bmt.1702457.
10
Disseminated toxoplasmosis following T cell-depleted related and unrelated bone marrow transplantation.T细胞去除的相关及非相关骨髓移植后播散性弓形虫病
Bone Marrow Transplant. 2000 May;25(9):969-73. doi: 10.1038/sj.bmt.1702370.