Department of Infectious Diseases, Clinical Infectious Diseases Hospital, Constanța, Romania.
Department of Doctoral School of Medicine, Ovidius University of Constanța, Constanta, Romania.
J Int Med Res. 2022 Oct;50(10):3000605221129154. doi: 10.1177/03000605221129154.
To identify carbapenem-resistant Enterobacteriaceae (CRE) in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; COVID-19) and to determine whether they had different risk factors for the acquisition of CRE than patients without COVID-19.
This retrospective single-centre, case-control study enrolled patients with and without COVID-19. The demographic, clinical, infection, colonization and mortality data were compared between the two groups.
A total of 38 patients with COVID-19 and 26 patients without COVID-19 were enrolled. The majority of isolates detected in COVID-19 patients were . Leukopenia at admission (odds ratio [OR] 4.70; 95% confidence interval [CI] 1.37, 16.10), invasive mechanical ventilation (OR 5.74; 95% CI 1.07, 30.63), carbapenem treatment (OR 5.09; 95% CI 1.21, 21.27) and corticosteroid treatment (OR 7.06; 95% CI 1.53, 32.39) were independent risk factors for CRE acquisition in COVID-19 patients. Intensive care unit (ICU) mortality was significantly higher in COVID-19 patients compared with patients without COVID-19 (OR 20.62; 95% CI 5.50, 77.23). Length of ICU stay increased the risk of death in patients with COVID-19 (subdistribution hazard ratio 3.81; 95% CI 1.33, 10.92).
CRE strains were more common in patients with COVID-19 and they had different risks for CRE compared with patients without COVID-19.
鉴定感染严重急性呼吸综合征冠状病毒 2（SARS-CoV-2；COVID-19）的患者中的耐碳青霉烯肠杆菌科（CRE），并确定他们获得 CRE 的风险因素是否与未感染 COVID-19 的患者不同。
本回顾性单中心病例对照研究纳入了 COVID-19 患者和非 COVID-19 患者。比较了两组患者的人口统计学、临床、感染、定植和死亡率数据。
共纳入 38 例 COVID-19 患者和 26 例非 COVID-19 患者。COVID-19 患者中检测到的多数分离株为. 入院时的白细胞减少症（优势比 [OR] 4.70；95%置信区间 [CI] 1.37, 16.10）、有创机械通气（OR 5.74；95% CI 1.07, 30.63）、碳青霉烯类药物治疗（OR 5.09；95% CI 1.21, 21.27）和皮质类固醇治疗（OR 7.06；95% CI 1.53, 32.39）是 COVID-19 患者获得 CRE 的独立危险因素。与非 COVID-19 患者相比，COVID-19 患者的 ICU 死亡率显著更高（OR 20.62；95% CI 5.50, 77.23）。ICU 住院时间的延长增加了 COVID-19 患者的死亡风险（亚分布危险比 3.81；95% CI 1.33, 10.92）。
COVID-19 患者中 CRE 菌株更为常见，与未感染 COVID-19 的患者相比，他们获得 CRE 的风险因素也不同。
