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心脏黏液瘤:单一三级医疗中心的经验。

Cardiac myxoma: single tertiary centre experience.

机构信息

Department of Cardiology, University Medical Center Ljubljana, Ljubljana, Slovenia.

Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

出版信息

Radiol Oncol. 2022 Oct 20;56(4):535-540. doi: 10.2478/raon-2022-0041. eCollection 2022 Dec 1.

Abstract

BACKGROUND

Although cardiac myxoma (CM) are rare and benign, they can cause life-threatening complications, such as hemodynamic disturbances or embolization. Surgical excision of the tumour is the treatment of choice. The aim of the study was to evaluate the epidemiological characteristics, clinical presentation, imaging findings, and outcomes of surgical treatment of patients with CM treated in the largest tertiary care centre in Slovenia.

PATIENTS AND METHODS

We retrospectively analysed the medical records of all patients referred to our institution between January 2005 and December 2020 and identified 39 consecutive adult patients with pathologically confirmed CM.

RESULTS

The average annual incidence of CM in the study was 3 per 2 million population per year. Patients were more often female (n = 25, 64%). The mean age at diagnosis was 63.1 ± 13.6 years. Dyspnoea was the most common presenting symptom (31%). CM was an incidental finding in 11 patients (28%). Seven patients presented with thromboembolic event (18%). Transthoracic echocardiography (TTE) was performed in all patients, however additional imaging was required in 22 patients (56%). All patients in our series were successfully treated surgically without in-hospital mortality. During the follow-up period (6 months to 16 years) three patients (8%) died, and all deaths were unrelated to CM. There was no recurrence of CM during the follow-up.

CONCLUSIONS

Our single-centre study confirms that CM is rare cardiac tumour with diverse clinical presentation. Our data shows data that CM might be more prevalent than considered before. Surgical resection of the tumour is safe with excellent short- and long-term outcomes.

摘要

背景

尽管心脏黏液瘤(CM)罕见且为良性,但它们可引起危及生命的并发症,如血流动力学紊乱或栓塞。手术切除肿瘤是首选的治疗方法。本研究旨在评估在斯洛文尼亚最大的三级保健中心接受治疗的 CM 患者的流行病学特征、临床表现、影像学表现和手术治疗结果。

患者和方法

我们回顾性分析了 2005 年 1 月至 2020 年 12 月期间我院收治的所有患者的病历,并确定了 39 例经病理证实的 CM 成年患者。

结果

本研究中 CM 的平均年发病率为每 200 万人中有 3 例。患者多为女性(n = 25,64%)。诊断时的平均年龄为 63.1 ± 13.6 岁。呼吸困难是最常见的首发症状(31%)。11 例患者(28%)为偶然发现。7 例患者出现血栓栓塞事件(18%)。所有患者均行经胸超声心动图(TTE)检查,但 22 例患者(56%)需要进一步影像学检查。我们系列中的所有患者均成功接受手术治疗,且无院内死亡。在随访期间(6 个月至 16 年),有 3 例患者(8%)死亡,且所有死亡均与 CM 无关。在随访期间未发现 CM 复发。

结论

我们的单中心研究证实,CM 是一种罕见的心脏肿瘤,具有多种临床表现。我们的数据表明,CM 的发病率可能比以前认为的更高。肿瘤切除术安全,且短期和长期结果均极佳。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93f9/9784375/0b8d13da4684/raon-56-535-g001.jpg

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