Saidu H, Mohammed I Y, Ishaq N A, Balarabe S A, Tukur J, Adedeji T A, Makinde O N, Adebayo R A, Umar H, Isezuo S A, Karaye K M
Department of Medicine, Bayero University, Kano, Kano State, Nigeria.
Department of Medicine, Murtala Mohammed Specialist Hospital, Kano, Kano State, Nigeria.
West Afr J Med. 2022 Oct 20;39(10):1057-1061.
There are few and conflicting reports in the literature about the relationship between parity and maternal cardiac function. The study aimed to assess the impact of parity on cardiac structure and function in apparently healthy pregnant women in Nigeria.
This was a cross-sectional study carried out in 3 tertiary centers in Kano, and 1 in Ile-Ife, Nigeria. 112 apparently healthy pregnant women were consecutively recruited between the 28th and 38th weeks of gestation, and their cardiac structure and function assessed using echocardiography. Left ventricular (LV) systolic dysfunction was defined as LV ejection fraction of below 50%, and diastolic dysfunction was graded using mitral filling and tissue Doppler velocities.
LV systolic dysfunction and diastolic dysfunction were found in 6 (5.4%) subjects and 20 (17.9%) subjects, respectively. Age (p= <0.0001), left atrial (LA) size (P<0.0001), interventricular septal thickness at end diastole (IVSD) (p= 0.005), posterior wall thickness at end diastole (PWTD) (p=0.004) and QRS duration (p= <0.0001) all increased progressively with higher parity, while tricuspid annular systolic excursion (p=0.320) decreased with higher parity. There was significant positive correlation between parity and age (r= 0.475, p= <0.0001), LA size (r=0.332, p= <0.0001), IVSD (r=0.264, p= 0.005) and PWTD (r= 0.343, p= <0.0001). LV systolic function was not significantly associated with parity.
Our findings suggested that parity was significantly associated with myocardial remodeling in apparently healthy pregnant women.
关于产次与孕产妇心脏功能之间的关系，文献中的报道较少且相互矛盾。本研究旨在评估产次对尼日利亚表面健康的孕妇心脏结构和功能的影响。
这是一项横断面研究，在卡诺的3个三级中心和尼日利亚伊费的1个中心进行。在妊娠第28至38周连续招募了112名表面健康的孕妇，并使用超声心动图评估她们的心脏结构和功能。左心室（LV）收缩功能障碍定义为左心室射血分数低于50%，舒张功能障碍使用二尖瓣充盈和组织多普勒速度进行分级。
分别在6名（5.4%）受试者和20名（17.9%）受试者中发现左心室收缩功能障碍和舒张功能障碍。年龄（p = <0.0001）、左心房（LA）大小（P<0.0001）、舒张末期室间隔厚度（IVSD）（p = 0.005）、舒张末期后壁厚度（PWTD）（p = 0.004）和QRS时限（p = <0.0001）均随着产次增加而逐渐增加，而三尖瓣环收缩期位移（p = 0.320）随着产次增加而降低。产次与年龄（r = 0.475，p = <0.0001）、LA大小（r = 0.332，p = <0.0001）、IVSD（r = 0.264，p = 0.005）和PWTD（r = 0.343，p = <0.0001）之间存在显著正相关。左心室收缩功能与产次无显著相关性。
我们的研究结果表明，产次与表面健康的孕妇心肌重塑显著相关。
