Chiba M, Igarashi K, Ohta H, Ohtaka M, Arakawa H, Masamune O
Jpn J Med. 1987 May;26(2):255-60. doi: 10.2169/internalmedicine1962.26.255.
Three cases of Crohn's disease (CD) which showed an elevation of creatine phosphokinase (CPK) during the course were reported. In two cases, elevations of serum myoglobin and aldolase were also observed which indicated rhabdomyolysis. Rhabdomyolysis occurred unrelated to the activity of CD and it was asymptomatic. It was unable to identify an apparent known cause for rhabdomyolysis. All three cases were under elemental diet (ED) but the causality of ED for rhabdomyolysis was uncertain. So far as we know, there is no report on rhabdomyolysis during ED treatment and there are only two reports in which rhabdomyolysis was documented in CD. The latter was rhabdomyolysis due to electrolyte depletion secondary to malabsorption in CD which was not encountered in our cases. Our department dealt only three cases of CD and all of them had an elevation of CPK which had been measured as one of routine blood chemistry in our hospital. These observations led to a following conclusion that subclinical rhabdomyolysis may be one of extra-intestinal complications of CD.
报告了3例克罗恩病（CD）患者，其病程中肌酸磷酸激酶（CPK）升高。其中2例还观察到血清肌红蛋白和醛缩酶升高，提示存在横纹肌溶解。横纹肌溶解与CD的活动无关，且无症状。未能确定横纹肌溶解的明显已知病因。所有3例患者均接受要素饮食（ED），但ED与横纹肌溶解之间的因果关系尚不确定。据我们所知，尚无关于ED治疗期间横纹肌溶解的报告，仅有2篇报告记录了CD患者出现横纹肌溶解。后者是由于CD吸收不良继发电解质耗竭导致的横纹肌溶解，我们的病例中未出现这种情况。我们科室仅诊治了3例CD患者，且所有患者的CPK均升高，CPK是我们医院常规血液生化检测项目之一。这些观察结果得出以下结论：亚临床横纹肌溶解可能是CD的肠外并发症之一。
